Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review

Nolan, Sarah J ORCID: 0000-0001-9988-2709, Sudell, Maria ORCID: 0000-0002-7919-4981, Tudur Smith, Catrin ORCID: 0000-0003-3051-1445 and Marson, Anthony G ORCID: 0000-0002-6861-8806
(2016) Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review. The Cochrane database of systematic reviews, 11 (11). CD001031-.

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BACKGROUND: This is an updated version of the original Cochrane review published in Issue 1, 2006 of the Cochrane Database of Systematic Reviews.Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment up to 70% of individuals with active epilepsy have the potential to become seizure-free and to go into long-term remission shortly after starting drug therapy with a single antiepileptic drug (AED) in monotherapy.The correct choice of first-line antiepileptic therapy for individuals with newly diagnosed seizures is of great importance. It is important that the choice of AEDs for an individual is made using the highest quality evidence regarding the potential benefits and harms of the various treatments. It is also important that the effectiveness and tolerability of AEDs appropriate to given seizure types are compared to one another.Carbamazepine or lamotrigine are first-line recommended treatments for new onset partial seizures and as a first- or second-line treatment for generalised tonic-clonic seizures. Performing a synthesis of the evidence from existing trials will increase the precision of the results for outcomes relating to efficacy and tolerability and may assist in informing a choice between the two drugs.

Item Type: Article
Uncontrolled Keywords: Neurosciences, Neurodegenerative, Clinical Research, Brain Disorders, Clinical Trials and Supportive Activities, Epilepsy, 6.1 Pharmaceuticals, 6 Evaluation of treatments and therapeutic interventions, Neurological, Adult, Anticonvulsants, Carbamazepine, Child, Epilepsies, Partial, Epilepsy, Generalized, Epilepsy, Tonic-Clonic, Humans, Lamotrigine, Randomized Controlled Trials as Topic, Recurrence, Triazines, Withholding Treatment
Depositing User: Symplectic Admin
Date Deposited: 23 May 2016 09:28
Last Modified: 15 Mar 2024 05:24
DOI: 10.1002/14651858.cd012065
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