Sputum bacterial load predicts multidrug-resistant tuberculosis in retreatment patients: a case-control study

Sander, MS, Vuchas, CY, Numfor, HN, Nsimen, AN, Abena, J-LF, Noeske, J, Van Deun, A and Morgan, KL (2016) Sputum bacterial load predicts multidrug-resistant tuberculosis in retreatment patients: a case-control study. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 20 (6). pp. 793-799.

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Official URL: http://dx.doi.org/10.5588/ijtld.15.0259

Abstract

<h4>Background</h4>Rapid and effective diagnosis of multidrug-resistant tuberculosis (MDR-TB) is an essential component of global tuberculosis (TB) control, but most MDR-TB cases are still not diagnosed.<h4>Objective</h4>To assess whether patient sputum bacterial load can be used to identify patients at increased risk of MDR-TB.<h4>Methods</h4>We used a case-control study and multivariable logistic regression models to investigate associations between MDR-TB and sputum bacterial load, as measured by semi-quantitative microscopy and automated time to detection (TTD) of liquid culture. We assessed data from retreatment TB patients with MDR-TB (cases) and from those without MDR-TB (controls) at a reference laboratory in Cameroon.<h4>Results</h4>MDR-TB was associated with a smear microscopy grade of 3+ (OR 21.9, 95%CI 6.2-76.8) or 2+ (OR 10.8, 95%CI 2.9-40.7), compared to a result of 1+, scanty or smear-negative among 80 MDR-TB cases and 521 controls. MDR-TB was associated with automated TTD of ⩿160 h (OR 2.2, 95%CI 1.1-4.7) compared to >160 h among a subpopulation of 47 cases and 350 controls.<h4>Conclusions</h4>A higher sputum bacterial load is associated with MDR-TB in retreatment patients in Cameroon.

Item Type:	Article
Uncontrolled Keywords:	MDR-TB, smear microscopy grade, bacillary load
Depositing User:	Symplectic Admin
Date Deposited:	04 Jul 2016 10:33
Last Modified:	19 Jan 2023 07:36
DOI:	10.5588/ijtld.15.0259
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3001451