Investigation of local brain invasion by cerebral metastases and implications for clinical management

Zakaria, R (2016) Investigation of local brain invasion by cerebral metastases and implications for clinical management. PhD thesis, University of Liverpool.

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Abstract

Brain metastases are common intracranial tumours which cause considerable morbidity and mortality. There are a variety of treatment modalities for brain metastases, including surgery, radiation and chemotherapy. There is, however, disagreement about the best combination of these therapies and prognostic scoring systems are not individualised. MRI is frequently obtained in the course of diagnosing these tumours and advanced MRI sequences, in particular diffusion MRI, which measures white matter disruption, may provide useful prognostic information which is patient and tumour specific. Finally, the interface between the brain metastasis and the surrounding brain has been poorly investigated compared to intrinsic brain tumours such as glioma, and may be a rich source of therapeutic targets and biomarkers. This thesis therefore aimed to derive biological and radiological markers of local brain metastasis invasion, intracranial progression and survival which may be used in clinical practice, whilst deepening scientific understanding of the brain-brain metastasis interface. Expression of the metastasis-inducing protein S100A4 was identified as a possible predictor of metastasis recurrence post operatively and OPN ... (continues)

Item Type:	Thesis (PhD)
Divisions:	Faculty of Health and Life Sciences > Faculty of Health and Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	26 Jul 2016 07:20
Last Modified:	10 Aug 2024 07:57
DOI:	10.17638/03001555
Supervisors:	Rudland, PR Jenkinson Sluming
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3001555