Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review

Lewis, Joseph M ORCID: 0000-0002-3837-5188, Macpherson, Peter ORCID: 0000-0002-0329-9613, Adams, Emily R, Ochodo, Eleanor, Sands, Anita and Taegtmeyer, Miriam (2015) Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review. AIDS, 29 (18). pp. 2465-2471.

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Abstract

<h4>Introduction</h4>Fourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal.<h4>Methods</h4>Clinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field evaluation studies in adults identified by a systematic literature search.<h4>Results</h4>Four studies with 17 381 participants from Australia, Swaziland, the United Kingdom and Malawi were identified. All reported 0% sensitivity of the HIV-1 p24 component for acute HIV-1 diagnosis; 26 acute infections were missed. Specificity ranged from 98.3 to 99.9%.<h4>Conclusion</h4>Fourth-generation RDTs are currently unsuitable for the detection of acute HIV-1.

Item Type:	Article
Uncontrolled Keywords:	acute infection, diagnostic accuracy, HIV, point-of-care testing, rapid diagnostic tests, systematic review
Depositing User:	Symplectic Admin
Date Deposited:	08 Jun 2016 14:26
Last Modified:	14 Mar 2024 18:01
DOI:	10.1097/QAD.0000000000000855
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3001598