Field, JK ORCID: 0000-0003-3951-6365, Duffy, SW, Baldwin, DR, Whynes, DK, Devaraj, A, Brain, KE, Eisen, T, Gosney, J, Green, BA, Holemans, JA et al (show 16 more authors)
(2016)
UK Lung Cancer RCT Pilot Screening Trial: baseline findings from the screening arm provide evidence for the potential implementation of lung cancer screening.
Thorax, 71 (2).
pp. 161-170.
Text
UK Lung Cancer RCT Pilot Screening Trial: baseline findings from the screening arm provide evidence for the potential implementation of lung cancer screening.pdf - Published version Download (1MB) |
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Abstract
BackgroundLung cancer screening using low-dose CT(LDCT) was shown to reduce lung cancer mortality by20% in the National Lung Screening Trial.MethodsThe pilot UK Lung Cancer Screening (UKLS)is a randomised controlled trial of LDCT screening forlung cancer versus usual care. A population-basedquestionnaire was used to identify high-risk individuals.CT screen-detected nodules were managed by a pre-specified protocol. Cost effectiveness was modelled withreference to the National Lung Cancer Screening Trialmortality reduction.Results247 354 individuals aged 50–75 years wereapproached; 30.7% expressed an interest, 8729(11.5%) were eligible and 4055 were randomised, 2028into the CT arm (1994 underwent a CT). Forty-twoparticipants (2.1%) had confirmed lung cancer, 34(1.7%) at baseline and 8 (0.4%) at the 12-month scan.28/42 (66.7%) had stage I disease, 36/42 (85.7%) hadstage I or II disease. 35/42 (83.3%) had surgicalresection. 536 subjects had nodules greater than50 mm3or 5 mm diameter and 41/536 were found tohave lung cancer. One further cancer was detected byfollow-up of nodules between 15 and 50 mm3at12 months. The baseline estimate for the incrementalcost-effectiveness ratio of once-only CT screening, underthe UKLS protocol, was £8466 per quality adjusted lifeyear gained (CI £5542 to £12 569).ConclusionsThe UKLS pilot trial demonstrated that itis possible to detect lung cancer at an early stage anddeliver potentially curative treatment in over 80% ofcases. Health economic analysis suggests that theintervention would be cost effective—this needs to beconfirmed using data on observed lung cancer mortalityreduction.
Item Type: | Article |
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Uncontrolled Keywords: | Humans, Lung Neoplasms, Tomography, X-Ray Computed, Mass Screening, Prognosis, Prevalence, Pilot Projects, Reproducibility of Results, Aged, Middle Aged, Female, Male, Early Detection of Cancer, Surveys and Questionnaires, United Kingdom |
Depositing User: | Symplectic Admin |
Date Deposited: | 28 Jun 2016 10:29 |
Last Modified: | 19 Jan 2023 07:35 |
DOI: | 10.1136/thoraxjnl-2015-207140 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3001866 |