Altered resting-state functional activity in posttraumatic stress disorder: A quantitative meta-analysis

Wang, T, Liu, J, Zhang, J, Zhan, W, Li, L, Wu, M, Huang, H, Zhu, H, Kemp, GJ ORCID: 0000-0002-8324-9666 and Gong, Q (2016) Altered resting-state functional activity in posttraumatic stress disorder: A quantitative meta-analysis. Scientific Reports, 6 (1). 27131-.

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Abstract

Many functional neuroimaging studies have reported differential patterns of spontaneous brain activity in posttraumatic stress disorder (PTSD), but the findings are inconsistent and have not so far been quantitatively reviewed. The present study set out to determine consistent, specific regional brain activity alterations in PTSD, using the Effect Size Signed Differential Mapping technique to conduct a quantitative meta-analysis of resting-state functional neuroimaging studies of PTSD that used either a non-trauma (NTC) or a trauma-exposed (TEC) comparison control group. Fifteen functional neuroimaging studies were included, comparing 286 PTSDs, 203 TECs and 155 NTCs. Compared with NTC, PTSD patients showed hyperactivity in the right anterior insula and bilateral cerebellum, and hypoactivity in the dorsal medial prefrontal cortex (mPFC); compared with TEC, PTSD showed hyperactivity in the ventral mPFC. The pooled meta-analysis showed hypoactivity in the posterior insula, superior temporal, and Heschl's gyrus in PTSD. Additionally, subgroup meta-analysis (non-medicated subjects vs. NTC) identified abnormal activation in the prefrontal-limbic system. In meta-regression analyses, mean illness duration was positively associated with activity in the right cerebellum (PTSD vs. NTC), and illness severity was negatively associated with activity in the right lingual gyrus (PTSD vs. TEC).

Item Type:	Article
Uncontrolled Keywords:	Brain, Limbic System, Cerebral Cortex, Prefrontal Cortex, Humans, Brain Mapping, Severity of Illness Index, Stress Disorders, Post-Traumatic, Time Factors, Female, Male
Depositing User:	Symplectic Admin
Date Deposited:	13 Jul 2016 11:38
Last Modified:	19 Jan 2023 07:34
DOI:	10.1038/srep27131
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3002027