Biomarkers for diagnosis of Wilson's disease

Ryan, Aidan, Nolan, Sarah J ORCID: 0000-0001-9988-2709 and Cook, Paul (2016) Biomarkers for diagnosis of Wilson's disease. Cochrane Database of Systematic Reviews, 2016 (6).

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Official URL: http://dx.doi.org/10.1002/14651858.cd012267

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows: The objective of this review is to determine the diagnostic accuracy of the index tests for WD. The index tests covered by this Cochrane review are caeruloplasmin, 24-hour urinary copper and hepatic copper content. We will investigate whether index tests should be performed in all individuals who have been recommended for testing for WD, or whether these tests should be limited to subgroups of individuals. Firstly, we will test differences in cut-off values and assay types as these are likely to have the most influence on heterogeneity. Depending on the number of studies included, we will perform further subgroup analyses considering age, gender, ethnicity, study design, assay type, clinical presentation (hepatic or neurological presentation or both).

Item Type:	Article
Depositing User:	Symplectic Admin
Date Deposited:	18 Jul 2016 10:22
Last Modified:	19 Jan 2023 07:33
DOI:	10.1002/14651858.cd012267
Open Access URL:	http://onlinelibrary.wiley.com/doi/10.1002/1465185...
Related URLs:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3002402