Pehlevan, C, Paoletti, P 
ORCID: 0000-0001-6131-0377 and Mahadevan, L
(2016)
Integrative neuromechanics of crawling in D. Melanogaster Larvae
eLife, 5 (2016JU).
e11031-.
ISSN 2050-084X, 2050-084X
Abstract
© Pehlevan et al.Locomotion in an organism is a consequence of the coupled interaction between brain, body and environment. Motivated by qualitative observations and quantitative perturbations of crawling in Drosophila melanogaster larvae, we construct a minimal integrative mathematical model for its locomotion. Our model couples the excitation-inhibition circuits in the nervous system to force production in the muscles and body movement in a frictional environment, thence linking neural dynamics to body mechanics via sensory feedback in a heterogeneous environment. Our results explain the basic observed phenomenology of crawling with and without proprioception, and elucidate the stabilizing role that proprioception plays in producing a robust crawling phenotype in the presence of biological perturbations. More generally, our approach allows us to make testable predictions on the effect of changing body-environment interactions on crawling, and serves as a step in the development of hierarchical models linking cellular processes to behavior.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 31 Biological Sciences, 32 Biomedical and Clinical Sciences, 3209 Neurosciences, Neurosciences, Bioengineering |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 25 Jul 2016 15:25 |
| Last Modified: | 05 Dec 2025 05:10 |
| DOI: | 10.7554/eLife.11031 |
| Open Access URL: | https://elifesciences.org/content/5/e11031 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3002520 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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