Role of peptidoglycan deacetylase in Staphylococcus aureus virulence and survival



Alorabi, JA
(2016) Role of peptidoglycan deacetylase in Staphylococcus aureus virulence and survival. PhD thesis, University of Liverpool.

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Abstract

Staphylococcus aureus is an opportunist human pathogen that colonises the anterior nares and is shed onto skin. The bacterium is most frequently a cause of skin and soft-tissue infections, yet is also a major cause of respiratory, urinary tract, bone, eye and brain infections. Evolution of the bacterium has selected strains that are more antibiotic resistant, particularly in the hospital environment and more recently in the community. The pathogen has the capacity for secreting a wide range of proteins that contribute to survival from host immunity and competing microflora. The bacterial cell wall is a vital structural polymer serving mechanical roles to protect bacteria from osmotic challenges and it serves as a scaffold for the attachment of many anchored proteins and anionic polymers for interaction with extracellular components. Peptidoglycan of S. aureus is modified by enzyme catalysed decoration of N-acetyl muramic acid with teichoic acid and O-acetylation which promotes lysozyme resistance. Further modification of teichoic acid engenders properties linked to colonisation and survival during the life-cycle. This research study sought to assign roles of S. aureus secreted proteins of unknown function ... (continues)

Item Type: Thesis (PhD)
Divisions: Faculty of Health and Life Sciences > Faculty of Health and Life Sciences
Depositing User: Symplectic Admin
Date Deposited: 15 Dec 2016 14:29
Last Modified: 17 Aug 2024 11:25
DOI: 10.17638/03002567
Supervisors:
  • Horsburgh, MAL
  • Rigden, DAN
URI: https://livrepository.liverpool.ac.uk/id/eprint/3002567