Functional connectivity with the default mode network is altered in fibromyalgia patients

Fallon, N ORCID: 0000-0003-1451-6983, Chiu, Y, Nurmikko, T and Stancak, A ORCID: 0000-0003-3323-3305 (2016) Functional connectivity with the default mode network is altered in fibromyalgia patients. PLoS ONE, 11 (7). e0159198-.

Other journal.pone.0159198.PDF - Author Accepted Manuscript Download (823kB)

Abstract

Fibromyalgia syndrome (FMS) patients show altered connectivity with the network maintaining ongoing resting brain activity, known as the default mode network (DMN). The connectivity patterns of DMN with the rest of the brain in FMS patients are poorly understood. This study employed seed-based functional connectivity analysis to investigate restingstate functional connectivity with DMN structures in FMS. Sixteen female FMS patients and 15 age-matched, healthy control subjects underwent T2-weighted resting-state MRI scanning and functional connectivity analyses using DMN network seed regions. FMS patients demonstrated alterations to connectivity between DMN structures and anterior midcingulate cortex, right parahippocampal gyrus, left superior parietal lobule and left inferior temporal gyrus. Correlation analysis showed that reduced functional connectivity between the DMN and the right parahippocampal gyrus was associated with longer duration of symptoms in FMS patients, whereas augmented connectivity between the anterior midcingulate and posterior cingulate cortices was associated with tenderness and depression scores. Our findings demonstrate alterations to functional connectivity between DMN regions and a variety of regions which are important for pain, cognitive and emotional processing in FMS patients, and which may contribute to the development or maintenance of chronic symptoms in FMS.

Item Type:	Article
Uncontrolled Keywords:	Brain, Nerve Net, Humans, Fibromyalgia, Case-Control Studies, Demography, Adult, Female
Depositing User:	Symplectic Admin
Date Deposited:	02 Aug 2016 11:00
Last Modified:	19 Jan 2023 07:32
DOI:	10.1371/journal.pone.0159198
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3002675