Abstract



Hobson, JJ ORCID: 0000-0003-2551-1774, Slater, R, Martin, P, Owen, A ORCID: 0000-0002-9819-7651 and Rannard, S ORCID: 0000-0002-6946-1097
(2016) Abstract. In: British Society for Nanomedicine Early Career Researcher Meeting, 2016-8-11 - 2016-8-12, Swansea.

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Abstract

Oil-in-Water Nanoemulsions loaded with either efavirenz or lopinavir were prepared using homogenisation/solvent evaporation technique to increase the concentration of drug in an aqueous environment. The ability of NEs to permeate intestinal barriers was assessed using Caco-2 transwell system, EFV and LPV loaded NEs were compared with aqueous solutions. NE LPV had significantly increased permeation compared to aqueous LPV, with apparent permeability (Papp) of 6.4 x 10-5 cm/s vs 2.7 x 10-6 cm/s (p= <0.05). Comparable results being observed for NE EFV compared to aqueous EFV, with Papp values of 1.1 x 10-5 cm/s and 8.2 x 10-6 cm/s respectively (p=<0.05).

Item Type: Conference or Workshop Item (Unspecified)
Uncontrolled Keywords: nanomedicine, nanoemulsion, HIV
Depositing User: Symplectic Admin
Date Deposited: 15 Aug 2016 10:38
Last Modified: 02 Oct 2023 22:19
DOI: 10.1002/jin2.14
Open Access URL: http://onlinelibrary.wiley.com/doi/10.1002/jin2.14...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3002944