Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection

Chukwuanukwu, RC, Onyenekwe, CC, Martinez-Pomares, L, Flynn, R ORCID: 0000-0001-5304-3088, Singh, S, Amilo, GI, Agbakoba, NR and Okoye, JO (2017) Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 187 (2). pp. 259-268.

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Official URL: http://dx.doi.org/10.1111/cei.12861

Abstract

Tuberculosis (TB) causes significant morbidity and mortality on a global scale. The African region has 24% of the world's TB cases. TB overlaps with other infectious diseases such as malaria and HIV, which are also highly prevalent in the African region. TB is a leading cause of death among HIV-positive patients and co-infection with HIV and TB has been described as a syndemic. In view of the overlapping epidemiology of these diseases, it is important to understand the dynamics of the immune response to TB in the context of co-infection. We investigated the cytokine response to purified protein derivative (PPD) in peripheral blood mononuclear cells from TB patients co-infected with HIV or malaria and compared it to that of malaria- and HIV-free TB patients. A total of 231 subjects were recruited for this study and classified into six groups; untreated TB-positive, TB positive subjects on TB drugs, TB- and HIV-positive, TB- and malaria-positive, latent TB and apparently healthy control subjects. Our results demonstrate maintenance of interferon (IFN)-γ production in HIV and malaria co-infected TB patients in spite of lower CD4 counts in the HIV-infected cohort. Malaria co-infection caused an increase in the production of the T helper type 2 (Th2)-associated cytokine interleukin (IL)-4 and the anti-inflammatory cytokine IL-10 in PPD-stimulated cultures. These results suggest that malaria co-infection diverts immune response against M. tuberculosis towards a Th-2/anti-inflammatory response which might have important consequences for disease progression.

Item Type:	Article
Uncontrolled Keywords:	co-infection, cytokines, HIV, malaria, tuberculosis
Depositing User:	Symplectic Admin
Date Deposited:	27 Sep 2016 10:18
Last Modified:	12 Oct 2023 09:00
DOI:	10.1111/cei.12861
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3003323