Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Gormley, P, Anttila, V, Winsvold, BS, Palta, P, Esko, T, Pers, TH, Farh, KH, Cuenca-Leon, E, Muona, M, Furlotte, NA
et al (show 67 more authors) (2016) Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (8). pp. 856-866.

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Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10-8) that mapped to 38 distinct genomic loci, including 28 loci not previously reported and a locus that to our knowledge is the first to be identified on chromosome X. In subsequent computational analyses, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies.

Item Type: Article
Uncontrolled Keywords: International Headache Genetics Consortium, Muscle, Smooth, Humans, Vascular Diseases, Genetic Predisposition to Disease, Genetic Markers, Case-Control Studies, Genomics, Polymorphism, Single Nucleotide, Migraine Disorders, Genome-Wide Association Study, Genetic Loci
Depositing User: Symplectic Admin
Date Deposited: 16 Sep 2016 08:57
Last Modified: 19 Jan 2023 07:30
DOI: 10.1038/ng.3598
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