Early impact of rotavirus vaccination in a large paediatric hospital in the UK

Hungerford, Dan ORCID: 0000-0002-9770-0163, Read, Jonathan, Cooke, RPD, Vivancos, Roberto, Iturriza-Gomara, Miren ORCID: 0000-0001-5816-6423, Allen, David James, French, Neil ORCID: 0000-0003-4814-8293 and Cunliffe, Nigel ORCID: 0000-0002-5449-4988 (2016) Early impact of rotavirus vaccination in a large paediatric hospital in the UK. Journal of Hospital Infection, 93 (02). pp. 117-120. (In Press)

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Abstract

The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0‒15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72‒90%) and 83% (95% CI: 66‒92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.

Item Type:	Article
Uncontrolled Keywords:	Epidemiology, Healthcare-associated infection, Rotavirus, Vaccination
Depositing User:	Symplectic Admin
Date Deposited:	19 Sep 2016 10:05
Last Modified:	19 Jan 2023 07:30
DOI:	10.1016/j.jhin.2015.12.010
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3003348