The Association of Hydration Status with Physical Signs, Symptoms and Survival in Advanced Cancer-The Use of Bioelectrical Impedance Vector Analysis (BIVA) Technology to Evaluate Fluid Volume in Palliative Care: An Observational Study

Nwosu, Amara Callistus ORCID: 0000-0003-0014-3741, Mayland, Catriona R ORCID: 0000-0002-1440-9953, Mason, Stephen ORCID: 0000-0002-3841-2313, Cox, Trevor F, Varro, Andrea and Ellershaw, John ORCID: 0000-0001-9789-3180 (2016) The Association of Hydration Status with Physical Signs, Symptoms and Survival in Advanced Cancer-The Use of Bioelectrical Impedance Vector Analysis (BIVA) Technology to Evaluate Fluid Volume in Palliative Care: An Observational Study PLOS ONE, 11 (9). e0163114-. ISSN 1932-6203, 1932-6203

Text The association of hydration with symptoms signs and survival - Plos One accpeted paper - self archive - 2016 - reduced file size copy.pdf - Author Accepted Manuscript Download (420kB)

Abstract

Background: Hydration in advanced cancer is a controversial area; however, current hydration assessments methods are poorly developed. Bioelectrical impedance vector analysis (BIVA) is an accurate hydration tool; however its application in advanced cancer has not been explored. This study used BIVA to evaluate hydration status in advanced cancer to examine the association of fluid status with symptoms, physical signs, renal biochemical measures and survival. Materials and methods: An observational study of 90 adults with advanced cancer receiving care in a UK specialist palliative care inpatient unit was conducted. Hydration status was assessed using BIVA in addition to assessments of symptoms, physical signs, performance status, renal biochemical measures, oral fluid intake and medications. The association of clinical variables with hydration was evaluated using regression analysis. A survival analysis was conducted to examine the influence of hydration status and renal failure. Results: The hydration status of participants was normal in 43 (47.8%), 'more hydrated' in 37 (41.1%) and 'less hydrated' in 10 (11.1%). Lower hydration was associated with increased symptom intensity (Beta = -0.29, p = 0.04) and higher scores for physical signs associated with dehydration (Beta = 10.94, p = 0.02). Higher hydration was associated with oedema (Beta = 2.55, p<0.001). Median survival was statistically significantly shorter in 'less hydrated' patients (44 vs. 68 days; p = 0.049) and in pre-renal failure (44 vs. 100 days; p = 0.003). Conclusions: In advanced cancer, hydration status was associated with clinical signs and symptoms. Hydration status and pre-renal failure were independent predictors of survival. Further studies can establish the utility of BIVA as a standardised hydration assessment tool and explore its potential research application, in order to inform the clinical management of fluid balance in patients with advanced cancer.

Item Type:	Article
Uncontrolled Keywords:	4203 Health Services and Systems, 42 Health Sciences, Clinical Research, Cancer, Kidney Disease, 7.2 End of life care, Cancer
Depositing User:	Symplectic Admin
Date Deposited:	20 Sep 2016 07:43
Last Modified:	23 May 2026 00:29
DOI:	10.1371/journal.pone.0163114
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3003380
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