Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis

Saneyasu, Takaoki, Akhtar, Riaz ORCID: 0000-0002-7963-6874 and Sakai, Takao ORCID: 0000-0002-7375-5450
(2016) Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis. BIOMED RESEARCH INTERNATIONAL, 2016. 2646212-.

[img] Text
2646212.pdf - Published version

Download (1MB)


Tissue and matrix stiffness affect cell properties during morphogenesis, cell growth, differentiation, and migration and are altered in the tissue remodeling following injury and the pathological progression. However, detailed molecular mechanisms underlying alterations of stiffness <i>in vivo</i> are still poorly understood. Recent engineering technologies have developed powerful techniques to characterize the mechanical properties of cell and matrix at nanoscale levels. Extracellular matrix (ECM) influences mechanical tension and activation of pathogenic signaling during the development of chronic fibrotic diseases. In this short review, we will focus on the present knowledge of the mechanisms of how ECM stiffness is regulated during the development of liver fibrosis and the molecules involved in ECM stiffness as a potential therapeutic target for liver fibrosis.

Item Type: Article
Uncontrolled Keywords: Liver, Extracellular Matrix, Animals, Humans, Mice, Liver Cirrhosis, Cell Physiological Phenomena
Depositing User: Symplectic Admin
Date Deposited: 19 Oct 2016 08:11
Last Modified: 19 Jan 2023 07:29
DOI: 10.1155/2016/2646212
Related URLs: