Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

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Feasey, NA, Hadfield, J, Keddy, KH, Dallman, TJ, Jacobs, J, Deng, X, Wigley, P, Barquist Barquist, L, Langridge, GC, Feltwell, T et al (show 37 more authors) , Harris, SR, Mather, AE, Fookes, M, Aslett, M, Msefula, C, Kariuki, S, Maclennan, CA, Onsare, RS, Weill, FX, Le Hello, S, Smith, AM, McClelland, M, Desai, P, Parry, CM ORCID: 0000-0001-7563-7282, Cheesbrough, J, French, N ORCID: 0000-0003-4814-8293, Campos, J, Chabalgoity, JA, Betancor, L, Hopkins, KL, Nair, S, Humphrey, TJ, Lunguya, O, Cogan, TA, Tapia, MD, Sow, SO, Tennant, SM, Bornstein, K, Levine, MM, Lacharme-Lora, L, Everett, DB, Kingsley, RA, Parkhill, J, Heyderman, RS, Dougan, G, Gordon, MA ORCID: 0000-0002-0629-0884 and Thomson, NR (2016) Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. Nature Genetics, 48 (10). pp. 1211-1217.

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Abstract

An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

Item Type:	Article
Uncontrolled Keywords:	Animals, Chickens, Humans, Salmonella enteritidis, Salmonella Infections, Enterocolitis, Poultry Diseases, Sequence Analysis, DNA, Adaptation, Biological, Genome, Bacterial, Plasmids, Income, Africa South of the Sahara, Female, Epidemics
Depositing User:	Symplectic Admin
Date Deposited:	18 Jan 2017 09:37
Last Modified:	19 Jan 2023 07:27
DOI:	10.1038/ng.3644
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3004045

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• Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. (deposited 18 Oct 2016 08:49)
  • Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. (deposited 18 Jan 2017 09:37) [Currently Displayed]