Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings



Feasey, NA, Hadfield, J, Keddy, KH, Dallman, TJ, Jacobs, J, Deng, X, Wigley, P, Barquist Barquist, L, Langridge, GC, Feltwell, T
et al (show 37 more authors) (2016) Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. Nature Genetics, 48 (10). 1211 - 1217.

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Abstract

An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 18 Jan 2017 09:37
Last Modified: 13 May 2021 12:10
DOI: 10.1038/ng.3644
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3004045

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