Orr, HA and Betancourt, AJ 
ORCID: 0000-0001-9351-1413
(2001)
Haldane's sieve and adaptation from the standing genetic variation.
Genetics, 157 (2).
pp. 875-884.
Abstract
We consider populations that adapt to a sudden environmental change by fixing alleles found at mutation-selection balance. In particular, we calculate probabilities of fixation for previously deleterious alleles, ignoring the input of new mutations. We find that "Haldane's sieve"--the bias against the establishment of recessive beneficial mutations--does not hold under these conditions. Instead probabilities of fixation are generally independent of dominance. We show that this result is robust to patterns of sex expression for both X-linked and autosomal loci. We further show that adaptive evolution is invariably slower at X-linked than autosomal loci when evolution begins from mutation-selection balance. This result differs from that obtained when adaptation uses new mutations, a finding that may have some bearing on recent attempts to distinguish between hitchhiking and background selection by contrasting the molecular population genetics of X-linked vs. autosomal loci. Last, we suggest a test to determine whether adaptation used new mutations or previously deleterious alleles from the standing genetic variation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | X Chromosome, Animals, Humans, Models, Statistical, Genetics, Population, Sex Factors, Adaptation, Biological, Genes, Recessive, Mutation, Alleles, Models, Genetic, Time Factors, Female, Male, Genetic Variation, Genetic Linkage |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 26 Oct 2016 10:10 |
| Last Modified: | 26 Feb 2024 05:25 |
| DOI: | 10.1093/genetics/157.2.875 |
| Open Access URL: | http://www.genetics.org/content/157/2/875 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3004111 |
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