Haldane's sieve and adaptation from the standing genetic variation


Orr, HA and Betancourt, AJ ORCID: 0000-0001-9351-1413 (2001) Haldane's sieve and adaptation from the standing genetic variation Genetics, 157 (2). pp. 875-884. ISSN 0016-6731, 1943-2631

Access the full-text of this item by clicking on the Open Access link.

Abstract

We consider populations that adapt to a sudden environmental change by fixing alleles found at mutation-selection balance. In particular, we calculate probabilities of fixation for previously deleterious alleles, ignoring the input of new mutations. We find that "Haldane's sieve" - The bias against the establishment of recessive beneficial mutations - Does not hold under these conditions. Instead probabilities of fixation are generally independent of dominance. We show that this result is robust to patterns of sex expression for both X-linked and autosomal loci. We further show that adaptive evolution is invariably slower at X-linked than autosomal loci when evolution begins from mutation-selection balance. This result differs from that obtained when adaptation uses new mutations, a finding that may have some bearing on recent attempts to distinguish between hitchhiking and background selection by contrasting the molecular population genetics of X-linked vs. autosomal loci. Last, we suggest a test to determine whether adaptation used new mutations or previously deleterious alleles from the standing genetic variation.

Item Type: Article
Uncontrolled Keywords: X Chromosome, Animals, Humans, Models, Statistical, Genetics, Population, Sex Factors, Adaptation, Biological, Genes, Recessive, Mutation, Alleles, Models, Genetic, Time Factors, Female, Male, Genetic Variation, Genetic Linkage
Depositing User: Symplectic Admin
Date Deposited: 26 Oct 2016 10:10
Last Modified: 24 Jan 2026 00:56
DOI: 10.1093/genetics/157.2.875
Open Access URL: http://www.genetics.org/content/157/2/875
Related Websites:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3004111
Disclaimer: The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate.
Altmetric
CORE (COnnecting REpositories)