Urinary biomarkers in childhood lupus nephritis

Smith, Eve MD and Beresford, Michael W ORCID: 0000-0002-5400-9911 (2017) Urinary biomarkers in childhood lupus nephritis. CLINICAL IMMUNOLOGY, 185. pp. 21-31.

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Abstract

Juvenile-onset systemic lupus erythematosus (JSLE) is a rare, severe multisystem autoimmune disease affecting the kidney (Lupus Nephritis, LN) in up to 80% of children. LN is more severe in children than adults, with potential for irreversible kidney damage requiring dialysis or transplant. Renal biopsy is currently the gold standard for diagnosing and monitoring LN, however, it is invasive and associated with complications. Urine biomarkers have been shown to be better than serum biomarkers in differentiating renal disease from other organ manifestations. Over the past decade, there have been an increasing number of studies investigating specific candidate biomarkers implicated in the pathogenesis of LN or screening for urinary biomarkers using hypothesis free methods. In this review, developments in urine biomarkers for LN will be reviewed, highlighting those that are of relevance to children and have gone through validation in independent international patient cohorts, bringing them close to clinical translation.

Item Type:	Article
Uncontrolled Keywords:	Urine, Biomarkers, Lupus nephritis, Childhood lupus, JSLE
Depositing User:	Symplectic Admin
Date Deposited:	28 Oct 2016 12:56
Last Modified:	19 Jan 2023 07:27
DOI:	10.1016/j.clim.2016.06.010
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3004180