The recent invasion of natural Drosophila simulans populations by the P-element

Kofler, Robert, Hill, Tom, Nolte, Viola, Betancourt, Andrea J ORCID: 0000-0001-9351-1413 and Schlötterer, Christian
(2015) The recent invasion of natural Drosophila simulans populations by the P-element. Proceedings of the National Academy of Sciences, 112 (21). 6659 - 6663.

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<jats:p>The P-element is one of the best understood eukaryotic transposable elements. It invaded <jats:italic>Drosophila melanogaster</jats:italic> populations within a few decades but was thought to be absent from close relatives, including <jats:italic>Drosophila simulans</jats:italic>. Five decades after the spread in <jats:italic>D. melanogaster</jats:italic>, we provide evidence that the P-element has also invaded <jats:italic>D. simulans</jats:italic>. P-elements in <jats:italic>D. simulans</jats:italic> appear to have been acquired recently from <jats:italic>D. melanogaster</jats:italic> probably via a single horizontal transfer event. Expression data indicate that the P-element is processed in the germ line of <jats:italic>D. simulans</jats:italic>, and genomic data show an enrichment of P-element insertions in putative origins of replication, similar to that seen in <jats:italic>D. melanogaster</jats:italic>. This ongoing spread of the P-element in natural populations provides a unique opportunity to understand the dynamics of transposable element spread and the associated piwi-interacting RNAs defense mechanisms.</jats:p>

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 31 Oct 2016 09:45
Last Modified: 23 Dec 2019 11:10
DOI: 10.1073/pnas.1500758112
Open Access URL: