Faster-X effects in two drosophila lineages

Ávila, V, De Procé, SM, Campos, JL, Borthwick, H, Charlesworth, B and Betancourt, AJ ORCID: 0000-0001-9351-1413 (2014) Faster-X effects in two drosophila lineages Genome Biology and Evolution, 6 (10). pp. 2968-2982. ISSN 1759-6653, 1759-6653

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Abstract

Under certain circumstances, X-linked loci are expected toexperiencemore adaptive substitutions thansimilar autosomal loci. Tolook for evidence of faster-X evolution, we analyzed the evolutionary rates of coding sequences in two sets of Drosophila species, the melanogaster andpseudoobscura clades,usingwhole-genomesequences.Oneof these, thepseudoobscura clade, contains a centric fusionbetweentheancestralXchromosomeandthe autosomalarmhomologous to3L inD.melanogaster. Thisoffersanopportunity to study the same loci in both an X-linked and an autosomal context, and to compare these loci with those that are only X-linked or only autosomal. We therefore investigated these clades for evidence of faster-X evolution with respect to nonsynonymous substitutions, finding mixed results. Overall, there was consistent evidence for a faster-X effect in the melanogaster clade, but not in the pseudoobscura clade, except for thecomparison between D. pseudoobscuraandits close relative, Drosophila persimilis.Ananalysisof polymorphism data on a set of genes fromD. pseudoobscura that evolve rapidly with respect to their protein sequences revealed no evidence for a faster-X effect with respect to adaptive protein sequence evolution; their rapid evolution is instead largely attributable to lower selective constraints. Faster-X evolution in the melanogaster cladewas not related to male-biased gene expression; surprisingly, however, female-biased genes showed evidence for faster-X effects, perhaps due to their sexually antagonistic effects inmales.

Item Type:	Article
Uncontrolled Keywords:	faster-X effect, Drosophila melanogaster, Drosophila pseudoobscura, positive selection, sex-biased gene expression
Depositing User:	Symplectic Admin
Date Deposited:	31 Oct 2016 09:44
Last Modified:	28 Feb 2026 15:20
DOI:	10.1093/gbe/evu229
Open Access URL:	http://gbe.oxfordjournals.org/content/6/10/2968.fu...
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3004203
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