De Procé, SM, Zeng, K, Betancourt, AJ 
ORCID: 0000-0001-9351-1413 and Charlesworth, B
(2012)
Selection on codon usage and base composition in Drosophila americana
Biology Letters, 8 (1).
pp. 82-85.
ISSN 1744-9561, 1744-957X
Abstract
We have used a polymorphism dataset on introns and coding sequences of X-linked loci in Drosophila americana to estimate the strength of selection on codon usage and/or biased gene conversion (BGC), taking into account a recent population expansion detected by a maximumlikelihood method. Drosophila americana was previously thought to have a stable demographic history, so that this evidence for a recent population expansion means that previous estimates of selection need revision. There was evidence for natural selection or BGC favouring GC over AT variants in introns, which is stronger for GC-rich than GC-poor introns. By comparing introns and coding sequences, we found evidence for selection on codon usage bias, which is much stronger than the forces acting on GC versus AT basepairs in introns. © 2011 The Royal Society.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Animals, Drosophila, Codon, Likelihood Functions, Sequence Alignment, Sequence Analysis, DNA, Population Dynamics, Base Composition, Base Sequence, Molecular Sequence Data, Missouri, Male, Selection, Genetic |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 31 Oct 2016 09:56 |
| Last Modified: | 24 Jan 2026 00:56 |
| DOI: | 10.1098/rsbl.2011.0601 |
| Open Access URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC32599... |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3004206 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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