Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration



Pisconti, A, Banks, GB, Babaeijandaghi, F, Dalla Betta, N, Rossi, FMV, Chamberlain, JS and Olwin, BB
(2016) Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration. Skeletal Muscle, 6.

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Abstract

Background The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan expressed in satellite cells, supports communication with the niche, providing cell interactions and signals to maintain quiescent satellite cells. Results Syndecan-3 ablation unexpectedly improves regeneration in repeatedly injured muscle and in dystrophic mice, accompanied by the persistence of sublaminar and interstitial, proliferating myoblasts. Additionally, muscle aging is improved in syndecan-3 null mice. Since syndecan-3 null myofiber-associated satellite cells downregulate Pax7 and migrate away from the niche more readily than wild type cells, syxndecan-3 appears to regulate satellite cell homeostasis and satellite cell homing to the niche. Conclusions Manipulating syndecan-3 provides a promising target for development of therapies to enhance muscle regeneration in muscular dystrophies and in aged muscle.

Item Type: Article
Uncontrolled Keywords: satellite cells, muscle regeneration, muscular dystrophy, niche, cell adhesion, cell migration, syndecan-3, pax7
Depositing User: Symplectic Admin
Date Deposited: 01 Nov 2016 08:13
Last Modified: 11 Oct 2021 20:13
DOI: 10.1186/s13395-016-0104-8
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3004231