Pisconti, A, Banks, GB, Babaeijandaghi, F, Dalla Betta, N, Rossi, FMV, Chamberlain, JS and Olwin, BB
(2016)
Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration.
Skeletal Muscle, 6 (1).
34-.
Text
Pisconti_2016.pdf - Published version Download (2MB) |
Abstract
Background The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan expressed in satellite cells, supports communication with the niche, providing cell interactions and signals to maintain quiescent satellite cells. Results Syndecan-3 ablation unexpectedly improves regeneration in repeatedly injured muscle and in dystrophic mice, accompanied by the persistence of sublaminar and interstitial, proliferating myoblasts. Additionally, muscle aging is improved in syndecan-3 null mice. Since syndecan-3 null myofiber-associated satellite cells downregulate Pax7 and migrate away from the niche more readily than wild type cells, syxndecan-3 appears to regulate satellite cell homeostasis and satellite cell homing to the niche. Conclusions Manipulating syndecan-3 provides a promising target for development of therapies to enhance muscle regeneration in muscular dystrophies and in aged muscle.
Item Type: | Article |
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Uncontrolled Keywords: | satellite cells, muscle regeneration, muscular dystrophy, niche, cell adhesion, cell migration, syndecan-3, pax7 |
Depositing User: | Symplectic Admin |
Date Deposited: | 01 Nov 2016 08:13 |
Last Modified: | 19 Jan 2023 07:26 |
DOI: | 10.1186/s13395-016-0104-8 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3004231 |