New Approaches to Investigate Drug-Induced Hypersensitivity

Ogese, Monday O ORCID: 0000-0002-1873-4032, Ahmed, Shaheda, Alferivic, Ana, Betts, Catherine J, Dickinson, Anne, Faulkner, Lee, French, Neil ORCID: 0000-0002-9376-3482, Gibson, Andrew, Hirschfield, Gideon M, Kammuller, Michael
et al (show 10 more authors) (2017) New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30 (1). pp. 239-259.

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The workshop on "New Approaches to Investigate Drug-Induced Hypersensitivity" was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and chemical basis of small molecule drug hypersensitivity, (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, and (3) identify the limitations, knowledge gaps, and challenges that limit the use of these assays and utilize the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective reviews the clinical and immunological bases of drug hypersensitivity and summarizes various experts' views on the different topics covered during the meeting.

Item Type: Article
Uncontrolled Keywords: Animals, Humans, Drug Hypersensitivity, Genetic Predisposition to Disease, Biological Assay, Risk Factors, Major Histocompatibility Complex, Phenotype, Drug Industry
Depositing User: Symplectic Admin
Date Deposited: 04 Nov 2016 11:14
Last Modified: 19 Jan 2023 07:26
DOI: 10.1021/acs.chemrestox.6b00333
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