Dong, Yue, Lin, Hungyen, Abolghasemi, Vahid, Gan, Lu, Zeitler, J Axel and Shen, Yao-Chun ORCID: 0000-0002-8915-1993
(2017)
Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography.
JOURNAL OF PHARMACEUTICAL SCIENCES, 106 (2).
pp. 546-553.
ISSN 0022-3549, 1520-6017
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Abstract
Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of B-scans are required that can quickly lead to an overwhelming amount of data. To better manage the data so as to generate a more accurate representation of the intra-tablet coating uniformity without compromising on the achievable axial resolution and imaging depth, we comprehensively examine an algebraic reconstruction technique with OCT to significantly reduce the data required. Specifically, a set of coated pharmaceutical tablets with film coating thickness in the range of 60-100 μm is investigated. Results obtained from performing the reconstruction reveal that only 30% of the acquired data are actually required leading to a faster convergence time and a generally good agreement with benchmark data against the intra-tablet coating uniformity measured with terahertz pulsed imaging technology.
Item Type: | Article |
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Uncontrolled Keywords: | coating, optical coherence tomography, imaging method, process analytical technology, tablet |
Depositing User: | Symplectic Admin |
Date Deposited: | 07 Nov 2016 08:24 |
Last Modified: | 07 Dec 2024 19:03 |
DOI: | 10.1016/j.xphs.2016.09.021 |
Open Access URL: | https://doi.org/10.1016/j.xphs.2016.09.021 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3004389 |