Validation of a Simple 0 to 10 Numerical Score (IBD-10) of Patient-reported Inflammatory Bowel Disease Activity for Routine Clinical Use


Subramanian, Sreedhar ORCID: 0000-0002-6483-1730, Asher, Rebecca, Weston, William, Rimmer, Michael, McConville, Adam, Malin, Alex, Jackson, Richard, Collins, Paul, Probert, Chris ORCID: 0000-0003-4550-0239, Dibb, Martyn et al (show 1 more authors) (2016) Validation of a Simple 0 to 10 Numerical Score (IBD-10) of Patient-reported Inflammatory Bowel Disease Activity for Routine Clinical Use. INFLAMMATORY BOWEL DISEASES, 22 (8). pp. 1902-1907.

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Abstract

<h4>Background</h4>Various physician- and patient-reported instruments exist for quantification of disease activity in inflammatory bowel diseases (IBD) but none are widely used in routine clinical practice. A simple patient-reported outcome measure might help inform clinical decision making. We evaluated a patient-reported 0 to 10 score of IBD activity (IBD-10) by correlation with conventional multicomponent activity indices.<h4>Methods</h4>A single-center prospective cross-sectional study was conducted in ambulant patients with IBD. Patients were asked to verbally rate the control of Crohn's disease (CD) or ulcerative colitis (UC) on a numerical scale from 0 to 10, with 10 indicating perfect control. Disease activity was assessed using Harvey-Bradshaw index for CD and simple clinical colitis activity index for UC.<h4>Results</h4>A total of 405 patients were included, of whom 209 (52%) had CD and 196 (48%) had UC. The median age was 41 (interquartile range, 27-55) years. IBD-10 correlated well with Harvey-Bradshaw Index (rs = -0.69, P < 0.001) and simple clinical colitis activity index (rs = -0.79, P < 0.001). An IBD-10 score of ≥7 predicted remission (defined by Harvey-Bradshaw index/simple clinical colitis activity index) with 90% sensitivity (95% confidence interval [CI], 86-94) and 75% specificity (95% CI, 67-82). The discriminatory ability of IBD-10 for remission was better for UC (area under the receiver operating characteristic curve, 0.93; 95% CI, 0.89-0.97) than for CD (area under the receiver operating characteristic curve, 0.86; 95% CI, 0.81-0.91; P = 0.035). An IBD-10 score of <7 correlated with treatment escalation.<h4>Conclusions</h4>The IBD-10 score correlates well with more complex clinical activity indices. Correlation was less strong for CD than for UC, possibly reflecting a weaker link in CD between stool frequency and the patient perspective of disease activity. The IBD-10 score could readily be used in routine clinical practice.

Item Type: Article
Uncontrolled Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, patient-reported outcome, IBD-10, Harvey-Bradshaw index, simple clinical colitis activity index
Depositing User: Symplectic Admin
Date Deposited: 09 Nov 2016 08:51
Last Modified: 19 Jan 2023 07:25
DOI: 10.1097/MIB.0000000000000803
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3004441
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