Green, David C, Ihli, Johannes, Kim, Yi-Yeoun, Chong, Samantha Y ORCID: 0000-0002-3095-875X, Lee, Phillip A, Empson, Christopher J and Meldrum, Fiona C
(2016)
Rapid Screening of Calcium Carbonate Precipitation in the Presence of Amino Acids: Kinetics, Structure, and Composition.
CRYSTAL GROWTH & DESIGN, 16 (9).
pp. 5174-5183.
Text
AS_390234308136962@1470050517815_content_1.pdf - Author Accepted Manuscript Download (2MB) |
Abstract
Soluble additives are widely used to control crystallization, leading to a definition of properties including size, morphology, polymorph, and composition. However, because of the number of potential variables in these experiments, it is typically extremely difficult to identify reaction conditions - as defined by solution compositions, temperatures, and combinations of additives - that give the desired product. This article introduces a high-throughput methodology which addresses this challenge and enables the streamlined preparation and characterization of crystalline materials. Using calcium carbonate precipitated in the presence of selected amino acids as a model system, we use well plates as microvolume crystallizers, and an accurate liquid-handling pipetting workstation for sample preparation. Following changes in the solution turbidity using a plate reader delivers information about the reaction kinetics, while semiautomated scanning electron microscopy, powder X-ray diffraction, and Raman microscopy provide structural information about the library of crystalline products. Of particular interest for the CaCO3 system is the development of fluorescence-based protocols which rapidly evaluate the amounts of the additives occluded within the crystals. Together, these methods provide a strategy for efficiently screening a broad reaction space, where this can both accelerate the ability to generate crystalline materials with target properties and develop our understanding of additive-directed crystallization.
Item Type: | Article |
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Depositing User: | Symplectic Admin |
Date Deposited: | 15 Nov 2016 15:01 |
Last Modified: | 19 Jan 2023 07:25 |
DOI: | 10.1021/acs.cgd.6b00741 |
Open Access URL: | https://www.researchgate.net/publication/305664336... |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3004508 |