Rapid Screening of Calcium Carbonate Precipitation in the Presence of Amino Acids: Kinetics, Structure, and Composition

Green, David C, Ihli, Johannes, Kim, Yi-Yeoun, Chong, Samantha Y ORCID: 0000-0002-3095-875X, Lee, Phillip A, Empson, Christopher J and Meldrum, Fiona C (2016) Rapid Screening of Calcium Carbonate Precipitation in the Presence of Amino Acids: Kinetics, Structure, and Composition. CRYSTAL GROWTH & DESIGN, 16 (9). pp. 5174-5183. ISSN 1528-7483, 1528-7505

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Abstract

Soluble additives are widely used to control crystallization, leading to a definition of properties including size, morphology, polymorph, and composition. However, because of the number of potential variables in these experiments, it is typically extremely difficult to identify reaction conditions - as defined by solution compositions, temperatures, and combinations of additives - that give the desired product. This article introduces a high-throughput methodology which addresses this challenge and enables the streamlined preparation and characterization of crystalline materials. Using calcium carbonate precipitated in the presence of selected amino acids as a model system, we use well plates as microvolume crystallizers, and an accurate liquid-handling pipetting workstation for sample preparation. Following changes in the solution turbidity using a plate reader delivers information about the reaction kinetics, while semiautomated scanning electron microscopy, powder X-ray diffraction, and Raman microscopy provide structural information about the library of crystalline products. Of particular interest for the CaCO<inf>3</inf> system is the development of fluorescence-based protocols which rapidly evaluate the amounts of the additives occluded within the crystals. Together, these methods provide a strategy for efficiently screening a broad reaction space, where this can both accelerate the ability to generate crystalline materials with target properties and develop our understanding of additive-directed crystallization.

Item Type:	Article
Uncontrolled Keywords:	3402 Inorganic Chemistry, 34 Chemical Sciences, 3406 Physical Chemistry
Depositing User:	Symplectic Admin
Date Deposited:	15 Nov 2016 15:01
Last Modified:	06 Jun 2025 20:37
DOI:	10.1021/acs.cgd.6b00741
Open Access URL:	https://www.researchgate.net/publication/305664336...
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3004508