Loley, Christina, Alver, Maris, Assimes, Themistocles L, Bjonnes, Andrew, Goel, Anuj, Gustafsson, Stefan, Hernesniemi, Jussi, Hopewell, Jemma C, Kanoni, Stavroula, Kleber, Marcus E et al (show 68 more authors)
(2016)
No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.
SCIENTIFIC REPORTS, 6 (1).
35278-.
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No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.pdf - Author Accepted Manuscript Download (482kB) |
Abstract
In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have only one. Also, one of the female X chromosomes may be inactivated. Therefore, special test statistics and quality control procedures are required. Thus, little is known about the role of X-chromosomal variants in CAD. To fill this gap, we conducted a comprehensive X-chromosome-wide meta-analysis including more than 43,000 CAD cases and 58,000 controls from 35 international study cohorts. For quality control, sex-specific filters were used to adequately take the special structure of X-chromosomal data into account. For single study analyses, several logistic regression models were calculated allowing for inactivation of one female X-chromosome, adjusting for sex and investigating interactions between sex and genetic variants. Then, meta-analyses including all 35 studies were conducted using random effects models. None of the investigated models revealed genome-wide significant associations for any variant. Although we analyzed the largest-to-date sample, currently available methods were not able to detect any associations of X-chromosomal variants with CAD.
Item Type: | Article |
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Uncontrolled Keywords: | Chromosomes, Human, X, Humans, Cohort Studies, Internationality, Female, Male, Coronary Artery Disease |
Depositing User: | Symplectic Admin |
Date Deposited: | 18 Nov 2016 17:04 |
Last Modified: | 19 Jan 2023 07:25 |
DOI: | 10.1038/srep35278 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3004613 |