25 Years of the <i>Onchocerca</i> <i>ochengi</i> Model

Makepeace, Benjamin L ORCID: 0000-0002-6100-6727 and Tanya, Vincent N
(2016) 25 Years of the <i>Onchocerca</i> <i>ochengi</i> Model. TRENDS IN PARASITOLOGY, 32 (12). pp. 966-978.

[img] Text
TREPAR-D-16-00157_R1_edited.pdf - Author Accepted Manuscript

Download (3MB)


Although of limited veterinary significance, Onchocerca ochengi has become famous as a natural model or 'analogue' of human onchocerciasis (river blindness), which is caused by Onchocerca volvulus. On the basis of both morphological and molecular criteria, O. ochengi is the closest extant relative of O. volvulus and shares several key natural history traits with the human pathogen. These include exploitation of the same group of insect vectors (blackflies of the Simulium damnosum complex) and formation of collagenous nodules with a similar histological structure to human nodules. Here, we review the contribution of this natural system to drug and vaccine discovery efforts, as well as to our basic biological understanding of Onchocerca spp., over the past quarter-century.

Item Type: Article
Uncontrolled Keywords: Animals, Humans, Simuliidae, Onchocerca, Onchocerciasis, Insect Vectors, Host-Parasite Interactions
Depositing User: Symplectic Admin
Date Deposited: 30 Nov 2016 09:14
Last Modified: 12 Oct 2023 15:51
DOI: 10.1016/j.pt.2016.08.013
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3004617