Novel brain expressed RNA identified at the MIR137 schizophrenia-associated locus

Gianfrancesco, O ORCID: 0000-0002-1613-5247, Warburton, A, Collier, DA, Bubb, VJ ORCID: 0000-0003-2763-7004 and Quinn, JP ORCID: 0000-0003-3551-7803
(2017) Novel brain expressed RNA identified at the MIR137 schizophrenia-associated locus. Schizophrenia Research, 184. pp. 109-115.

[img] Text
SUBMISSION 23.11 Novel brain expressed RNA.docx - Author Accepted Manuscript

Download (2MB)


Genome-wide association studies (GWAS) have identified a locus on chromosome 1p21.3 to be highly associated with schizophrenia. A microRNA, MIR137, within this locus has been proposed as the gene causally associated with schizophrenia, due to its known role as a regulator of neuronal development and function. However, the involvement of other genes within this region, including DPYD (dihydropyrimidine dehydrogenase), is also plausible. In this communication, we describe a previously uncharacterised, brain-expressed RNA, EU358092, within the schizophrenia-associated region at 1p21.3. As we observed for MIR137, EU358092 expression was modulated in response to psychoactive drug treatment in the human SH-SY5Y neuroblastoma cell line. Bioinformatic analysis of publically available CNS expression data indicates that MIR137 and EU358092 are often co-expressed in vivo. A potential regulatory domain for expression of EU358092 is identified by bioinformatic analysis and its regulatory function is confirmed by reporter gene assays. These data suggest a potentially important role for EU358092 in the aetiology of schizophrenia, either individually or in combination with other genes at this locus.

Item Type: Article
Uncontrolled Keywords: EU358092, lncRNA, microRNA-137, Schizophrenia
Depositing User: Symplectic Admin
Date Deposited: 23 Nov 2016 17:06
Last Modified: 19 Jan 2023 07:25
DOI: 10.1016/j.schres.2016.11.034
Related URLs: