Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials



O' Neill, Paul M, Sabbani, Sunil, Nixon, Gemma L, Schnaderbeck, Matthew, Roberts, Natalie L, Shore, Emma R, Riley, Christopher, Murphy, Ben, McGillan, Paul, Ward, Stephen A
et al (show 2 more authors) (2016) Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials. TETRAHEDRON, 72 (40). pp. 6118-6126.

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Abstract

An efficient route to the synthesis of potent antimalarial aryloxy 1,2,4,5-tetraoxanes is described that permits parallel synthesis for Structure–Activity Relationship (SAR) investigations. Brief details of the in vitro and in vivo antimalarial evaluation are included which enables identification of antimalarial leads for further development. Also described is an improved approach to the synthesis of a selected late-lead compound in just four or five synthetic steps from commercially available starting materials.

Item Type: Article
Uncontrolled Keywords: Peroxide chemistry, Antimalarial, Reductive amination, Chemoselective reduction, Medicinal chemistry
Depositing User: Symplectic Admin
Date Deposited: 25 Nov 2016 11:17
Last Modified: 19 Jan 2023 07:25
DOI: 10.1016/j.tet.2016.08.043
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3004665