Exercise-induced improvements in liver fat and endothelial function are not sustained 12 months following cessation of exercise supervision in nonalcoholic fatty liver disease


Pugh, CJA, Sprung, VS ORCID: 0000-0002-2666-4986, Jones, H, Richardson, P, Shojaee-Moradie, F, Umpleby, AM, Green, DJ, Cable, NT, Trenell, MI, Kemp, GJ ORCID: 0000-0002-8324-9666 et al (show 1 more authors) (2016) Exercise-induced improvements in liver fat and endothelial function are not sustained 12 months following cessation of exercise supervision in nonalcoholic fatty liver disease. INTERNATIONAL JOURNAL OF OBESITY, 40 (12). pp. 1927-1930.

[img] Text
Pugh 2016 IJO text.pdf - Author Accepted Manuscript
Download (511kB)
[img] Text
Pugh 2016 IJO table.pdf - Author Accepted Manuscript
Download (360kB)

Abstract

Supervised exercise reduces liver fat and improves endothelial function, a surrogate of cardiovascular disease (CVD) risk, in nonalcoholic fatty liver disease (NAFLD). We hypothesised that after a 16-week supervised exercise program, patients would maintain longer-term improvements in cardiorespiratory fitness, liver fat and endothelial function. Ten NAFLD patients (5/5 males/females, age 51±13 years, body mass index 31±3 kg m<sup>-2</sup> (mean±s.d.)) underwent a 16-week supervised moderate-intensity exercise intervention. Biochemical markers, cardiorespiratory fitness (VO<sub>2peak</sub>), subcutaneous, visceral and liver fat (measured by magnetic resonance imaging and spectroscopy respectively) and brachial artery flow-mediated dilation (FMD) were assessed at baseline, after 16 weeks of supervised training and 12 months after ending supervision. Despite no significant change in body weight, there were significant improvements in VO<sub>2peak</sub> (6.5 ml kg<sup>-1</sup> min<sup>-1</sup> (95% confidence interval 2.8, 10.1); P=0.003), FMD (2.9% (1.5, 4.2); P=0.001), liver transaminases (P<0.05) and liver fat (-10.1% (-20.6, 0.5); P=0.048) immediately after the 16-week supervised training. Nevertheless, 12 months after ending supervision, VO<sub>2peak</sub> (0.9 ml kg<sup>-1</sup> min<sup>-1</sup> (-3.3, 5.1); P=0.65), FMD (-0.07% (-2.3, 2.2); P=0.95), liver transaminases (P>0.05) and liver fat (1.4% (-13.0, 15.9); P=0.83) were not significantly different from baseline. At 12 months following cessation of supervision, exercise-mediated improvements in liver fat and other cardiometabolic variables had reversed with cardiorespiratory fitness at baseline levels. Maintenance of high cardiorespiratory fitness and stability of body weight are critical public health considerations for the treatment of NAFLD (Clinicaltrials.gov identifier: NCT01834300).

Item Type: Article
Uncontrolled Keywords: Liver, Brachial Artery, Endothelium, Vascular, Adipose Tissue, Humans, Obesity, Recurrence, Treatment Outcome, Exercise Therapy, Longitudinal Studies, Pilot Projects, Patient Compliance, Middle Aged, Female, Male, Non-alcoholic Fatty Liver Disease
Depositing User: Symplectic Admin
Date Deposited: 11 Jan 2017 08:20
Last Modified: 19 Jan 2023 07:24
DOI: 10.1038/ijo.2016.123
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3004836
Dimensions
Altmetric
CORE (COnnecting REpositories)