Altered Functional Connectivity in an Aged Rat Model of Postoperative Cognitive Dysfunction: A Study Using Resting-State Functional MRI

Xie, Peng, Yu, Tian, Fu, Xiaoyun, Tu, Ye, Zou, Yan, Lui, Su, Zhao, Xuna, Huang, Xiaoqi, Kemp, Graham J ORCID: 0000-0002-8324-9666 and Gong, Qiyong (2013) Altered Functional Connectivity in an Aged Rat Model of Postoperative Cognitive Dysfunction: A Study Using Resting-State Functional MRI. PLOS ONE, 8 (5). e64820-.

Text Altered functional connectivity in an aged rat model of postoperative cognitive dysfunction: a study using resting-state functional MRI.pdf - Published version Download (483kB)

Abstract

<h4>Background</h4>Postoperative cognitive impairment is a common complication after cardiac and major non-cardiac surgery in the elderly, but its causes and mechanisms remain unclear. The purpose of the current study was to use resting-state functional magnetic resonance imaging (fMRI) to explore changes in the functional connectivity, i.e. the synchronization of low frequency fluctuation (LFF), in an animal model of cognitive impairment in aged rats.<h4>Methods</h4>Aged (22 months) rats were anaesthetized with 40 µg/kg fentanyl and 500 µg/kg droperidol (intraperitoneal) for splenectomy. Cognitive function was assessed using Y maze prior to operation and on postoperative days 1, 3 and 9. To evaluate functional connectivity, resting-state fMRI data were acquired using a 3T MR imaging system with a 4 channel phase array rat head coil.<h4>Results</h4>Cognitive function was impaired at postoperative days 1 and 3 compared with preoperative. Significant synchronized LFF was detected bilaterally in the primary somatosensory cortex and hippocampus preoperatively. By contrast, no significant LFF synchronization was detected in the right primary somatosensory cortex and right hippocampus on postoperative days 1 and 3, although the pattern of functional connectivity had become almost normal by day 9.<h4>Conclusion</h4>Splenectomy performed under neuroleptic anaesthesia triggers a cognitive decline that is associated with altered spontaneous neuronal activity in the cortex and hippocampus.

Item Type:	Article
Additional Information:	## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords:	Nerve Net, Animals, Rats, Rats, Sprague-Dawley, Disease Models, Animal, Magnetic Resonance Imaging, Postoperative Period, Spatial Behavior, Maze Learning, Memory, Cognition Disorders, Aging, Rest, Female
Depositing User:	Symplectic Admin
Date Deposited:	13 Dec 2016 10:22
Last Modified:	19 Jan 2023 07:24
DOI:	10.1371/journal.pone.0064820
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3004839