Integrating muscle cell biochemistry and whole-body physiology in humans: <SUP>31</SUP>P-MRS data from the InSight trial



Edwards, Lindsay M, Kemp, Graham J ORCID: 0000-0002-8324-9666, Dwyer, Renee M, Walls, Justin T, Fuller, Huddy, Smith, Steven R and Earnest, Conrad P
(2013) Integrating muscle cell biochemistry and whole-body physiology in humans: <SUP>31</SUP>P-MRS data from the InSight trial. SCIENTIFIC REPORTS, 3 (1). 1182-.

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Abstract

We acquired (31)P-MRS data from skeletal muscle of subjects of mixed gender and ethnicity, combined with a panel of physiological characteristics, and tested several long-standing hypotheses regarding relationships between muscle cell biochemistry and whole-body physiology with unusually high statistical power. We hypothesized that i) whole-body VO(2)max would correlate with muscle respiratory capacity, ii) resting muscle phosphocreatine concentration ([PCr]) would negatively correlate with delta efficiency and iii) muscle mitochondrial function would positively correlate with both resting VO(2) and total daily energy expenditure (TDEE). Muscle respiratory capacity explained a quarter of the variation in VO(2)max (r(2) = 26, p < .001, n = 87). There was an inverse correlation between muscle [PCr] and delta efficiency (r = -23, p = 046, n = 87). There was also a correlation between [PCr] recovery halftime and TDEE (r = -23, p = 035, n = 87). Our data not only provide insights into muscle cell chemistry and whole-body physiology but our mixed cohort means that our findings are broadly generalizable.

Item Type: Article
Additional Information: ## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords: Muscle, Skeletal, Mitochondria, Humans, Phosphorus Isotopes, Phosphocreatine, Magnetic Resonance Imaging, Radionuclide Imaging, Cohort Studies, Longitudinal Studies, Energy Metabolism, Oxygen Consumption, Hydrogen-Ion Concentration, Principal Component Analysis, Adult, Female, Male
Depositing User: Symplectic Admin
Date Deposited: 13 Dec 2016 10:23
Last Modified: 10 Oct 2023 21:24
DOI: 10.1038/srep01182
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3004841