The STR/ort mouse model of spontaneous osteoarthritis - an update

Staines, KA, Poulet, B, Wentworth, DN and Pitsillides, AA (2017) The STR/ort mouse model of spontaneous osteoarthritis - an update. OSTEOARTHRITIS AND CARTILAGE, 25 (6). pp. 802-808.

Access the full-text of this item by clicking on the Open Access link.

Text Strort review update 2016.pdf - Submitted version Download (395kB)

Abstract

Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes.

Item Type:	Article
Uncontrolled Keywords:	STR/ort, Osteoarthritis, Articular cartilage, Subchondral bone
Depositing User:	Symplectic Admin
Date Deposited:	13 Dec 2016 16:22
Last Modified:	19 Jan 2023 07:24
DOI:	10.1016/j.joca.2016.12.014
Open Access URL:	https://www.sciencedirect.com/science/article/pii/...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3004863