Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury

Carr, Daniel F, Ayehunie, Seyoum, Davies, Andrea, Duckworth, Carrie A ORCID: 0000-0001-9992-7540, French, Stephanie, Hall, Neil, Hussain, Syed, Mellor, Howard R, Norris, Alan, Park, B Kevin ORCID: 0000-0001-8384-824X
et al (show 11 more authors) (2017) Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury. PHARMACOLOGY & THERAPEUTICS, 172. pp. 181-194.

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Adverse drug reactions affecting the gastrointestinal (GI) tract are a serious burden on patients, healthcare providers and the pharmaceutical industry. GI toxicity encompasses a range of pathologies in different parts of the GI tract. However, to date no specific mechanistic diagnostic/prognostic biomarkers or translatable pre-clinical models of GI toxicity exist. This review will cover the current knowledge of GI ADRs, existing biomarkers and models with potential application for toxicity screening/monitoring. We focus on the current gaps in our knowledge, the potential opportunities and recommend that a systematic approach is needed to identify mechanism-based GI biomarkers with potential for clinical translation.

Item Type: Article
Uncontrolled Keywords: Gastrointestinal, Toxicity, Adverse drug reaction, Biomarker, In vitro, In vivo
Depositing User: Symplectic Admin
Date Deposited: 14 Dec 2016 15:27
Last Modified: 19 Jan 2023 07:24
DOI: 10.1016/j.pharmthera.2017.01.002
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