A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease



Walker, L ORCID: 0000-0002-3827-4387, Griffiths, MJ, McGill, F, Lewthwaite, P, Sills, GJ ORCID: 0000-0002-3389-8713, Jorgensen, A, Antoine, DJ, Solomon, T ORCID: 0000-0001-7266-6547, Marson, AG ORCID: 0000-0002-6861-8806 and Pirmohamed, M ORCID: 0000-0002-7534-7266
(2016) A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. Biomarkers, 22 (7). 635 - 642.

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Abstract

Aims: To determine whether a correlation exists between paired cerebrospinal fluid (CSF) and serum levels of a novel inflammatory biomarker, high-mobility group box 1 (HMGB1), in different neurological conditions. Methods: HMGB1 was measured in the serum and CSF of 46 neurological patients (18 idiopathic intracranial hypertension [IIH], 18 neurological infection/inflammation [NII] and 10 Rasmussen’s encephalitis [RE]). Results: Mean serum (± SD) HMGB1 levels were 1.43 ± 0.54, 25.28 ± 27.9 and 1.89 ± 1.49 ng/ml for the patients with IIH, NII and RE, respectively. Corresponding mean (± SD) CSF levels were 0.35 ± 0.22, 4.48 ± 6.56 and 2.24 ± 2.35 ng/ml. Both CSF and serum HMGB1 was elevated in NII. Elevated CSF HMGB1 was demonstrated in RE. There was no direct correlation between CSF and serum levels of HMGB1. Conclusion: Serum HMGB1 cannot be used as a surrogate measure for CSF levels. CSF HMGB1 was elevated in NII and RE, its role as a prognostic/stratification biomarker needs further study.

Item Type: Article
Uncontrolled Keywords: High-mobility group box 1 (HMGB1), Biomarker, Cerebrospinal fluid
Depositing User: Symplectic Admin
Date Deposited: 03 Jan 2017 10:48
Last Modified: 24 Feb 2021 18:12
DOI: 10.1080/1354750X.2016.1265003
Open Access URL: http://www.tandfonline.com/doi/abs/10.1080/1354750...
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3005032

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