Walker, L ORCID: 0000-0002-3827-4387, Griffiths, MJ, McGill, F ORCID: 0000-0002-0903-9046, Lewthwaite, P, Sills, GJ ORCID: 0000-0002-3389-8713, Jorgensen, A ORCID: 0000-0002-6977-9337, Antoine, DJ, Solomon, T ORCID: 0000-0001-7266-6547, Marson, AG ORCID: 0000-0002-6861-8806 and Pirmohamed, M ORCID: 0000-0002-7534-7266
(2016)
A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease.
Biomarkers, 22 (7).
pp. 635-642.
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Abstract
Aims: To determine whether a correlation exists between paired cerebrospinal fluid (CSF) and serum levels of a novel inflammatory biomarker, high-mobility group box 1 (HMGB1), in different neurological conditions. Methods: HMGB1 was measured in the serum and CSF of 46 neurological patients (18 idiopathic intracranial hypertension [IIH], 18 neurological infection/inflammation [NII] and 10 Rasmussen’s encephalitis [RE]). Results: Mean serum (± SD) HMGB1 levels were 1.43 ± 0.54, 25.28 ± 27.9 and 1.89 ± 1.49 ng/ml for the patients with IIH, NII and RE, respectively. Corresponding mean (± SD) CSF levels were 0.35 ± 0.22, 4.48 ± 6.56 and 2.24 ± 2.35 ng/ml. Both CSF and serum HMGB1 was elevated in NII. Elevated CSF HMGB1 was demonstrated in RE. There was no direct correlation between CSF and serum levels of HMGB1. Conclusion: Serum HMGB1 cannot be used as a surrogate measure for CSF levels. CSF HMGB1 was elevated in NII and RE, its role as a prognostic/stratification biomarker needs further study.
Item Type: | Article |
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Uncontrolled Keywords: | High-mobility group box 1 (HMGB1), Biomarker, Cerebrospinal fluid |
Depositing User: | Symplectic Admin |
Date Deposited: | 03 Jan 2017 10:48 |
Last Modified: | 19 Jan 2023 07:23 |
DOI: | 10.1080/1354750X.2016.1265003 |
Open Access URL: | http://www.tandfonline.com/doi/abs/10.1080/1354750... |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3005032 |
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A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. (deposited 01 Dec 2016 08:31)
- A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. (deposited 03 Jan 2017 10:48) [Currently Displayed]