Effect<i>S</i> of non-nutritive s<i>W</i>eetened beverages on appet<i>IT</i>e during a<i>C</i>tive weig<i>H</i>t loss (SWITCH): Protocol for a randomized, controlled trial assessing the effects of non-nutritive sweetened beverages compared to water during a 12-week weight loss period and a follow up weight maintenance period

Masic, U, Harrold, JA ORCID: 0000-0002-0899-4586, Christiansen, P, Cuthbertson, DJ ORCID: 0000-0002-6128-0822, Hardman, CA ORCID: 0000-0002-0744-6019, Robinson, E ORCID: 0000-0003-3586-5533 and Halford, JCG ORCID: 0000-0003-1629-3189 (2017) Effect<i>S</i> of non-nutritive s<i>W</i>eetened beverages on appet<i>IT</i>e during a<i>C</i>tive weig<i>H</i>t loss (SWITCH): Protocol for a randomized, controlled trial assessing the effects of non-nutritive sweetened beverages compared to water during a 12-week weight loss period and a follow up weight maintenance period. CONTEMPORARY CLINICAL TRIALS, 53. pp. 80-88.

Text CCT (2016) SWITCH Methodology Paper.pdf - Author Accepted Manuscript Download (903kB)

Abstract

<h4>Background</h4>Acute and medium-term intervention studies suggest that non-nutritive sweeteners (NNS) are beneficial for weight loss, however there is limited human data on the long-term effects of consuming NNS on weight loss, maintenance, and appetite. Further research is therefore required to elucidate the prolonged impact of NNS consumption on these outcome measures.<h4>Methods/design</h4>A randomized parallel groups design will be used to assess whether regular NNS beverage intake is equivalent to a water control in promoting weight loss over 12-weeks (weekly weight loss sessions; Phase I), then supporting weight maintenance over 40-weeks (monthly sessions; Phase II) and subsequently independent weight maintenance over 52-weeks (Phase III) in 432 participants. A subset of these participants (n=116) will complete laboratory-based appetite probe days (15 sessions; 3 sessions each at baseline, at the start of phase I and the end of each phase). A separate subset (n=50) will complete body composition scans (DXA) at baseline and at the end of each phase. All participants will regularly be weighed and will complete questionnaires and cognitive tasks to assess changes in body weight and appetitive behaviours. Measures of physical activity and biochemical markers will also be taken.<h4>Discussion</h4>The trial will assess the efficacy of NNS beverages compared to water during a behavioural weight loss and maintenance programme. We aim to understand whether the impact of NNS on weight, dietary adherence and well-being are beneficial or transient and effects on prolonged successful weight loss and weight maintenance through sustained changes in appetite and eating behaviour.<h4>Trial registration</h4>Clinical Trials: NCT02591134; registered: 23.10.2015.

Item Type:	Article
Uncontrolled Keywords:	Weight loss, Obesity, Low calorie sweeteners (LCS), Non-nutritive sweeteners (NNS), Body weight, Sugar-sweetened beverages (SSB)
Depositing User:	Symplectic Admin
Date Deposited:	04 Jan 2017 15:30
Last Modified:	12 Oct 2023 13:50
DOI:	10.1016/j.cct.2016.12.012
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3005094