Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells


Ghezzi, S, Cooper, L, Rubio, A, Pagani, I, Capobianchi, MR, Ippolito, G, Pelletier, J, Meneghetti, MCZ, Lima, MA, Skidmore, MA et al (show 3 more authors) (2017) Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells Antiviral Research, 140. pp. 13-17. ISSN 0166-3542, 1872-9096

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Abstract

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).

Item Type: Article
Uncontrolled Keywords: Zika virus (ZIKV), Neural progenitor cells, Heparin, Cell death
Depositing User: Symplectic Admin
Date Deposited: 16 Jan 2017 10:06
Last Modified: 01 Mar 2026 05:40
DOI: 10.1016/j.antiviral.2016.12.023
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3005232
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