Ghezzi, S, Cooper, L, Rubio, A, Pagani, I, Capobianchi, MR, Ippolito, G, Pelletier, J, Meneghetti, MCZ, Lima, MA, Skidmore, MA et al (show 3 more authors)
(2017)
Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells.
Antiviral Research, 140.
13 - 17.
![[img]](https://livrepository.liverpool.ac.uk/style/images/fileicons/text.png) |
Text
AVR_2017.pdf - Accepted Version Download (1MB) |
Abstract
The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Zika virus (ZIKV), Neural progenitor cells, Heparin, Cell death |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 16 Jan 2017 10:06 |
| Last Modified: | 18 Aug 2022 14:11 |
| DOI: | 10.1016/j.antiviral.2016.12.023 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3005232 |
Dimensions
Dimensions
