Sound understanding of environmental, health and safety, clinical, and market aspects is imperative to clinical translation of nanomedicines

Rosslein, Matthias, Liptrott, Neill J ORCID: 0000-0002-5980-8966, Owen, Andrew ORCID: 0000-0002-9819-7651, Boisseau, Patrick, Wick, Peter and Herrmann, Inge K (2017) Sound understanding of environmental, health and safety, clinical, and market aspects is imperative to clinical translation of nanomedicines. NANOTOXICOLOGY, 11 (2). pp. 147-149.

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Official URL: http://dx.doi.org/10.1080/17435390.2017.1279361

Abstract

Nanotechnology has transformed materials engineering. However, despite much excitement in the scientific community, translation of nanotechnology-based developments has suffered from significant translational gaps, particularly in the field of biomedicine. Of the many concepts investigated, very few have entered routine clinical application. Safety concerns and associated socioeconomic uncertainties, together with the lack of incentives for technology transfer, are undoubtedly imposing significant hurdles to effective clinical translation of potentially game-changing developments. Commercialisation aspects are only rarely considered in the early stages and in many cases, the market is not identified early on in the process, hence precluding market-oriented development. However, methodologies and in-depth understanding of mechanistic processes existing in the environmental, health and safety (EHS) community could be leveraged to accelerate translation. Here, we discuss the most important stepping stones for (nano)medicine development along with a number of suggestions to facilitate future translation.

Item Type:	Article
Uncontrolled Keywords:	Environmental toxicology, nanomedicine, risk assessment, translation, particle characterisation
Depositing User:	Symplectic Admin
Date Deposited:	16 Jan 2017 09:52
Last Modified:	19 Jan 2023 07:20
DOI:	10.1080/17435390.2017.1279361
Open Access URL:	http://www.tandfonline.com/doi/abs/10.1080/1743539...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3005235