Identification of drug-and drug-metabolite immune responses originating from both naive and memory T cells

Gibson, Andrew, Faulkner, Lee, Wood, Sally, Park, B Kevin ORCID: 0000-0001-8384-824X and Naisbitt, Dean J (2017) Identification of drug-and drug-metabolite immune responses originating from both naive and memory T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140 (2). 578-+.

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Official URL: http://dx.doi.org/10.1016/j.jaci.2016.11.032

Abstract

Both naïve and memory T-cells from drug-naive donors can be stimulated by parent drug and drug haptens. Thus, drug-derived antigens can stimulate naïve T-cells alongside pre-existing memory T-cells through proposed heterologous immunity with an as yet undetermined peptide antigen.

Item Type:	Article
Uncontrolled Keywords:	T-Lymphocyte Subsets, Humans, Drug Hypersensitivity, Lymphocyte Activation, Immunologic Memory, Phenotype, Biomarkers
Depositing User:	Symplectic Admin
Date Deposited:	30 Jan 2017 10:48
Last Modified:	19 Jan 2023 07:19
DOI:	10.1016/j.jaci.2016.11.032
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3005434