Re-assessing the total burden of norovirus circulating in the United Kingdom population

Harris, John P ORCID: 0000-0001-9606-9480, Iturriza-Gomara, Miren ORCID: 0000-0001-5816-6423 and O'Brien, Sarah J ORCID: 0000-0003-2896-8999 (2017) Re-assessing the total burden of norovirus circulating in the United Kingdom population. VACCINE, 35 (6). pp. 853-855.

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Abstract

The second Infectious Intestinal Diseases study (IID2) estimated the incidence of norovirus in the UK at 47/1000 population (three million cases annually). Clinically significant norovirus was defined using a cycle threshold (ct) value of <30; a more stringent cut-off than used in diagnostic laboratories. The low infectious dose of norovirus means asymptomatic individuals potentially contribute to ongoing transmission. Using a less stringent but diagnostically relevant threshold increases the estimation of the population burden of norovirus infection by around 26% to 59/1000 person years (95% CI 52.32-64.98), equating to 3.7 million norovirus infections annually (3.3-4.1 million). With possible vaccines on the horizon for norovirus, having a good estimate of the total burden of norovirus infection, as well as symptomatic disease will be useful in helping to guide vaccination policy when candidate vaccines become available.

Item Type:	Article
Uncontrolled Keywords:	Norovirus, Gastrointestinal infections, Calicivirus, Infectious diseases
Depositing User:	Symplectic Admin
Date Deposited:	31 Jan 2017 16:21
Last Modified:	19 Jan 2023 07:19
DOI:	10.1016/j.vaccine.2017.01.009
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3005477