Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.



Wain, LV, Shrine, N, Artigas, MS, Erzurumluoglu, AM, Noyvert, B, Bossini-Castillo, L, Obeidat, M, Henry, AP, Portelli, MA, Hall, RJ
et al (show 96 more authors) (2017) Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nature Genetics, 49 (3). 416 - 425.

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Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 × 10(-49)), and we observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest genetic risk score deciles in UK Biobank. The 97 signals show enrichment in genes for development, elastic fibers and epigenetic regulation pathways. We highlight targets for drugs and compounds in development for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and describe targets for potential drug repositioning from other clinical indications.

Item Type: Article
Uncontrolled Keywords: Understanding Society Scientific Group, Geisinger-Regeneron DiscovEHR Collaboration, genetics research, genome-wide association studies, respiratory tract diseases
Depositing User: Symplectic Admin
Date Deposited: 02 Mar 2017 10:07
Last Modified: 13 May 2021 15:10
DOI: 10.1038/ng.3787
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3005979