Novel genetic loci associated with hippocampal volume

Collapse authors list.
Hibar, Derrek P, Adams, Hieab HH, Jahanshad, Neda, Chauhan, Ganesh, Stein, Jason L, Hofer, Edith, Renteria, Miguel E, Bis, Joshua C, Arias-Vasquez, Alejandro, Ikram, M Kamran et al (show 322 more authors) , Desrivieres, Sylvane, Vernooij, Meike W, Abramovic, Lucija, Alhusaini, Saud, Amin, Najaf, Andersson, Micael, Arfanakis, Konstantinos, Aribisala, Benjamin S, Armstrong, Nicola J, Athanasiu, Lavinia, Axelsson, Tomas, Beecham, Ashley H, Beiser, Alexa, Bernard, Manon, Blanton, Susan H, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brickman, Adam M, Carmichael, Owen, Chakravarty, M Mallar, Chen, Qiang, Ching, Christopher RK, Chouraki, Vincent, Cuellar-Partida, Gabriel, Crivello, Fabrice, Den Braber, Anouk, Nhat, Trung Doan, Ehrlich, Stefan, Giddaluru, Sudheer, Goldman, Aaron L, Gottesman, Rebecca F, Grimm, Oliver, Griswold, Michael E, Guadalupe, Tulio, Gutman, Boris A, Hass, Johanna, Haukvik, Unn K, Hoehn, David, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Jorgensen, Kjetil N, Karbalai, Nazanin, Kasperaviciute, Dalia, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Liewald, David CM, Lopez, Lorna M, Luciano, Michelle, Macare, Christine, Marquand, Andre F, Matarin, Mar, Mather, Karen A, Mattheisen, Manuel, McKay, David R, Milaneschi, Yuri, Maniega, Susana Munoz, Nho, Kwangsik, Nugent, Allison C, Nyquist, Paul, Loohuis, Loes M Olde, Oosterlaan, Jaap, Papmeyer, Martina, Pirpamer, Lukas, Puetz, Benno, Ramasamy, Adaikalavan, Richards, Jennifer S, Risacher, Shannon L, Roiz-Santianez, Roberto, Rommelse, Nanda, Ropele, Stefan, Rose, Emma J, Royle, Natalie A, Rundek, Tatjana, Saemann, Philipp G, Saremi, Arvin, Satizabal, Claudia L, Schmaal, Lianne, Schork, Andrew J, Shen, Li, Shin, Jean, Shumskaya, Elena, Smith, Albert V, Sprooten, Emma, Strike, Lachlan T, Teumer, Alexander, Tordesillas-Gutierrez, Diana, Toro, Roberto, Trabzuni, Daniah, Trompet, Stella, Vaidya, Dhananjay, Van der Grond, Jeroen, Van der Lee, Sven J, Van der Meer, Dennis, Van Donkelaar, Marjolein MJ, Van Eijk, Kristel R, Van Erp, Theo GM, Van Rooij, Daan, Walton, Esther, Westlye, Lars T, Whelan, Christopher D, Windham, Beverly G, Winkler, Anderson M, Wittfeld, Katharina, Woldehawariat, Girma, Wolf, Christiane, Wolfers, Thomas, Yanek, Lisa R, Yang, Jingyun, Zijdenbos, Alex, Zwiers, Marcel P, Agartz, Ingrid, Almasy, Laura, Ames, David, Amouyel, Philippe, Andreassen, Ole A, Arepalli, Sampath, Assareh, Amelia A, Barral, Sandra, Bastin, Mark E, Becker, Diane M, Becker, James T, Bennett, David A, Blangero, John, van Bokhoven, Hans, Boomsma, Dorret I, Brodaty, Henry, Brouwer, Rachel M, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Bulayeva, Kazima B, Cahn, Wiepke, Calhoun, Vince D, Cannon, Dara M, Cavalleri, Gianpiero L, Cheng, Ching-Yu, Cichon, Sven, Cookson, Mark R, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Czisch, Michael, Dale, Anders M, Davies, Gareth E, De Craen, Anton JM, De Geus, Eco JC, De Jager, Philip L, De Zubicaray, Greig I, Deary, Ian J, Debette, Stephanie, DeCarli, Charles, Delanty, Norman, Depondt, Chantal, DeStefano, Anita, Dillman, Allissa, Djurovic, Srdjan, Donohoe, Gary, Drevets, Wayne C, Duggirala, Ravi, Dyer, Thomas D, Enzinger, Christian, Erk, Susanne, Espeseth, Thomas, Fedko, Iryna O, Fernandez, Guillen, Ferrucci, Luigi, Fisher, Simon E, Fleischman, Debra A, Ford, Ian, Fornage, Myriam, Foroud, Tatiana M, Fox, Peter T, Francks, Clyde, Fukunaga, Masaki, Gibbs, J Raphael, Glahn, David C, Gollub, Randy L, Goring, Harald HH, Green, Robert C, Gruber, Oliver, Gudnason, Vilmundur, Guelfi, Sebastian, Haberg, Asta K, Hansell, Narelle K, Hardy, John, Hartman, Catharina A, Hashimoto, Ryota, Hegenscheid, Katrin, Heinz, Andreas, Le Hellard, Stephanie, Hernandez, Dena G, Heslenfeld, Dirk J, Ho, Beng-Choon, Hoekstra, Pieter J, Hoffmann, Wolfgang, Hofman, Albert, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Hottenga, Jouke-Jan, Huentelman, Matthew, Pol, Hilleke E Hulshoff, Ikeda, Masashi, Jack, Clifford R Jr, Jenkinson, Mark, Johnson, Robert, Joensson, Erik G, Jukema, J Wouter, Kahn, Rene S, Kanai, Ryota, Kloszewska, Iwona, Knopman, David S, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Lemaitre, Herve, Liu, Xinmin, Longo, Dan L, Lopez, Oscar L, Lovestone, Simon, Martinez, Oliver, Martinot, Jean-Luc, Mattay, Venkata S, McDonald, Colm, McIntosh, Andrew M, McMahon, Francis J, McMahon, Katie L, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mohnke, Sebastian, Montgomery, Grant W, Morris, Derek W, Mosley, Thomas H, Muhleisen, Thomas W, Mueller-Myhsok, Bertram ORCID: 0000-0002-0719-101X, Nalls, Michael A, Nauck, Matthias, Nichols, Thomas E, Niessen, Wiro J, Nothen, Markus M, Nyberg, Lars, Ohi, Kazutaka, Olvera, Rene L, Ophoff, Roel A, Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda WJH, Pike, G Bruce, Potkin, Steven G, Psaty, Bruce M, Reppermund, Simone, Rietschel, Marcella, Roffman, Joshua L, Romanczuk-Seiferth, Nina, Rotter, Jerome I, Ryten, Mina, Sacco, Ralph L, Sachdev, Perminder S, Saykin, Andrew J, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter R, Sigursson, Sigurdur, Simmons, Andrew, Singleton, Andrew, Sisodiya, Sanjay M, Smith, Colin, Smoller, Jordan W, Soininen, Hilkka, Steen, Vidar M, Stott, David J, Sussmann, Jessika E, Thalamuthu, Anbupalam, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Tsolaki, Magda, Tzourio, Christophe, Uitterlinden, Andre G, Hernandez, Maria C Valdes, Van der Brug, Marcel, van der Lugt, Aad, van der Wee, Nic JA, Van Haren, Neeltje EM, van't Ent, Dennis, Van Tol, Marie-Jose, Vardarajan, Badri N, Vellas, Bruno, Veltman, Dick J, Voelzke, Henry, Walter, Henrik, Wardlaw, Joanna M, Wassink, Thomas H, Weale, Michael E, Weinberger, Daniel R, Weiner, Michael W, Wen, Wei, Westman, Eric, White, Tonya, Wong, Tien Y, Wright, Clinton B, Zielke, Ronald H, Zonderman, Alan B, Martin, Nicholas G, Van Duijn, Cornelia M, Wright, Margaret J, Longstreth, WT, Schumann, Gunter, Grabe, Hans J, Franke, Barbara, Launer, Lenore J, Medland, Sarah E, Seshadri, Sudha, Thompson, Paul M and Ikram, M Arfan (2017) Novel genetic loci associated with hippocampal volume. NATURE COMMUNICATIONS, 8 (1). 13624-. ISSN 2041-1723, 2041-1723

	Text Novel genetic loci associated with hippocampal volume.pdf - Published version Download (1MB)
	Atom XML (admin) 2017-05-12T11:29:36Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-12T12:25:59Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-12T13:25:13Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-12T14:25:16Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-12T15:25:23Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-12T16:25:52Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-12T17:25:15Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-12T18:26:06Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-12T19:25:33Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-12T20:25:52Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-12T21:26:14Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-12T22:26:56Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-12T23:32:40Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-13T01:27:35Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-13T02:26:54Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-13T03:26:59Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-13T04:49:42Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-13T05:26:51Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-13T06:26:01Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-13T07:26:21Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-13T08:26:46Z.atom - Unspecified Download (0B)
	Atom XML (admin) 2017-05-13T09:26:05Z.atom - Unspecified Download (0B)

Abstract

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r_g=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

Item Type:	Article
Uncontrolled Keywords:	Hippocampus, Humans, Alzheimer Disease, Genetic Predisposition to Disease, Glycoproteins, Microtubule-Associated Proteins, Nerve Tissue Proteins, Organ Size, Cohort Studies, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Female, Male, Genome-Wide Association Study, Young Adult, Methionine Sulfoxide Reductases, Genetic Loci, Dipeptidyl Peptidase 4, Protein Serine-Threonine Kinases
Depositing User:	Symplectic Admin
Date Deposited:	23 Feb 2017 08:18
Last Modified:	06 Dec 2024 21:41
DOI:	10.1038/ncomms13624
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3006001