Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study.


Park, Joong-Won, Chen, Minshan, Colombo, Massimo, Roberts, Lewis R ORCID: 0000-0001-7885-8574, Schwartz, Myron, Chen, Pei-Jer, Kudo, Masatoshi ORCID: 0000-0002-4102-3474, Johnson, Philip ORCID: 0000-0003-1404-0209, Wagner, Samuel, Orsini, Lucinda S et al (show 1 more authors) (2015) Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study. Liver international : official journal of the International Association for the Study of the Liver, 35 (9). pp. 2155-2166.

[img] Text
Park BRIDGE MS Submitted Liver International subm confirmation screenshot_6-5-14.pdf - Author Accepted Manuscript
Download (28kB)

Abstract

<h4>Background & aims</h4>Hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. The global HCC BRIDGE study was a multiregional, large-scale, longitudinal cohort study undertaken to improve understanding of real-life management of patients with HCC, from diagnosis to death.<h4>Methods</h4>Data were collected retrospectively from January 2005 to September 2012 by chart reviews of eligible patients newly diagnosed with HCC at participating institutions.<h4>Results</h4>Forty-two sites in 14 countries contributed final data for 18 031 patients. Asia accounted for 67% of patients, Europe for 20% and North America for 13%. As expected, the most common risk factor was hepatitis C virus in North America, Europe and Japan, and hepatitis B virus in China, South Korea and Taiwan. The most common Barcelona Clinic Liver Cancer stage at diagnosis was C in North America, Europe, China and South Korea, and A in Taiwan and Japan. Across all stages, first HCC treatment was most frequently transarterial chemoembolization in North America, Europe, China and South Korea, percutaneous ethanol injection or radiofrequency ablation in Japan and resection in Taiwan. Survival from first HCC treatment varied significantly by region, with median overall survival not reached for Taiwan and 60, 33, 31, 24 and 23 months for Japan, North America, South Korea, Europe and China respectively (P < 0.0001).<h4>Conclusions</h4>Initial results from the BRIDGE study confirm previously reported regional trends in patient demographic characteristics and HCC risk factors, document the heterogeneity of treatment approaches across regions/countries and underscore the need for earlier HCC diagnosis worldwide.

Item Type: Article
Uncontrolled Keywords: Humans, Hepatitis B, Hepatitis C, Carcinoma, Hepatocellular, Liver Neoplasms, Ethanol, Catheter Ablation, Embolization, Therapeutic, Risk Factors, Survival Analysis, Retrospective Studies, Longitudinal Studies, Adult, Aged, Middle Aged, Disease Management, North America, Asia, Europe, Female, Male
Depositing User: Symplectic Admin
Date Deposited: 02 Mar 2017 13:28
Last Modified: 19 Jan 2023 07:14
DOI: 10.1111/liv.12818
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3006130
Dimensions
Altmetric
CORE (COnnecting REpositories)