Waters, EM, Neill, DR 
ORCID: 0000-0002-7911-8153, Kaman, B, Sahota, JS, Clokie, MRJ, Winstanley, C ORCID: 0000-0002-2662-8053 and Kadioglu, A ORCID: 0000-0003-1137-6321
(2017)
Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa.
Thorax, 72 (7).
pp. 666-667.
ISSN 0040-6376, 1468-3296
Abstract
With an increase in cases of multidrug-resistant Pseudomonas aeruginosa, alternative and adjunct treatments are needed, leading to renewed interest in bacteriophage therapy. There have been few clinically relevant studies of phage therapy against chronic lung infections. Using a novel murine model that uses a natural respiratory inhalation route of infection, we show that phage therapy is an effective treatment against chronic P. aeruginosa lung infections. We also show efficacy against P. aeruginosa in a biofilm-associated cystic fibrosis lung-like environment. These studies demonstrate the potential for phage therapy in the treatment of established and recalcitrant chronic respiratory tract infections.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Animals, Mice, Inbred BALB C, Mice, Biofilms, Pseudomonas aeruginosa, Pseudomonas Infections, Respiratory Tract Infections, Disease Models, Animal, Chronic Disease, Colony Count, Microbial, Time Factors, Phage Therapy |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 10 Mar 2017 10:43 |
| Last Modified: | 01 Mar 2026 05:48 |
| DOI: | 10.1136/thoraxjnl-2016-209265 |
| Open Access URL: | http://thorax.bmj.com/content/thoraxjnl/early/2017... |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3006315 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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