Lugos, MD
(2017)
The effect of cytomegalovirus infection on follicular lymphoma biology.
PhD thesis, University of Liverpool.
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Abstract
Follicular lymphoma (FL) is an incurable human B-cell neoplasm that follows a chronic relapsing course requiring multiple treatment episodes and culminating in therapy resistance and/or large-cell transformation. The disease is notable for its clinical variability but the biological basis for this variability is poorly understood. In addition to intrinsic genetic and epigenetic alterations that drive tumour growth, an intricate cross-talk between malignant B cells and the immune microenvironment have been shown to play a significant role in the pathogenesis of FL. This thesis tests the hypothesis that some of the heterogeneity of FL might result from chronic infection with cytomegalovirus (CMV). The latter affects ~50% of the adult population and has been linked to premature immune senescence and expedited age-related alterations in the T cell repertoire. I reasoned that CMV infection might have two distinct effects in FL: (1) by accelerating immune senescence, it might increase the risk of treated-related infection; and (2) by altering the lymphoma microenvironment, it might modulate the effect of chemo-immunotherapy. To address these questions, I was able to access stored PMBCs, serum and tissue samples ... (continues)
| Item Type: | Thesis (PhD) |
|---|---|
| Divisions: | Faculty of Health and Life Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 21 Aug 2017 06:21 |
| Last Modified: | 30 Sep 2024 02:15 |
| DOI: | 10.17638/03006414 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3006414 |
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