Midbrain Gliofibroma Presenting in Adulthood following "Cure" of a Childhood Intraventricular Pilocytic Astrocytoma

Ahmad, Mohammad U, Barborie, Atik, Pizer, Barry, Husband, David, Mallucci, Conor ORCID: 0000-0002-5509-0547 and Jenkinson, Michael D ORCID: 0000-0003-4587-2139
(2017) Midbrain Gliofibroma Presenting in Adulthood following "Cure" of a Childhood Intraventricular Pilocytic Astrocytoma. PEDIATRIC NEUROSURGERY, 52 (3). pp. 151-154.

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<h4>Introduction</h4>Gliofibromas are rare biphasic tumours with a good prognosis that usually occur in childhood. Rare adult spinal cases have been treated with radiotherapy. This report describes the case of a gliofibroma occurring in a young adult 10 years after treatment for a childhood pilocytic astrocytoma.<h4>Case</h4>A 14-year-old female underwent complete resection of a right lateral ventricle pilocytic astrocytoma confirmed on postoperative magnetic resonance imaging (MRI). At the age of 17, the tumour recurred, and a second complete resection was performed. Due to the early recurrence, she was placed on long-term MRI surveillance. At the age of 23, an enhancing left midbrain tumour was identified that was suspected to be a recurrent pilocytic astrocytoma. Following surgical resection the histopathology revealed a gliofibroma. Due to the growth of further tumour nodules she was treated with fractionated radiotherapy. There is no disease recurrence after 36 months of follow-up, and the patient remains well.<h4>Discussion</h4>Gliofibromas are tumours which usually occur in childhood; this case report identifies a rare occurrence in an adult. The childhood intraventricular pilocytic astrocytoma was in an anatomically distinct location to the midbrain gliofibroma. Radiotherapy can control these tumours, and follow-up is required to understand the long-term outcome and prognosis.

Item Type: Article
Uncontrolled Keywords: Gliofibroma, Pilocytic astrocytoma, Surgery, Radiotherapy
Depositing User: Symplectic Admin
Date Deposited: 24 Mar 2017 15:17
Last Modified: 19 Jan 2023 07:09
DOI: 10.1159/000455920
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3006611