Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children

McWilliam, SJ ORCID: 0000-0002-0509-7425, Antoine, DJ, Sabbisetti, VS, Pearce, RE, Jorgensen, AL ORCID: 0000-0002-6977-9337, Lin, Y, Leeder, JS, Bonventre, JV, Smyth, RL and Pirmohamed, M ORCID: 0000-0002-7534-7266 (2014) Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children. Biomarkers in Medicine, 8 (10). pp. 1189-1197.

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Abstract

Aim: The aim of this study was to establish reference intervals in healthy children for two novel urinary biomarkers of acute kidney injury, kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Materials & Methods: Urinary biomarkers were determined in samples from children in the UK (n = 120) and the USA (n = 171) using both Meso Scale Discovery (MSD) and Luminex-based analytical approaches. Results: 95% reference intervals for each biomarker in each cohort are presented and stratified by sex or ethnicity where necessary, and age-related variability is explored using quantile regression. We identified consistently higher NGAL concentrations in females than males (p < 0.0001), and lower KIM-1 concentrations in African–Americans than Caucasians (p = 0.02). KIM-1 demonstrated diurnal variation, with higher concentrations in the morning (p < 0.001). Conclusion: This is the first report of reference intervals for KIM-1 and NGAL using two analytical methods in a healthy pediatric population in both UK and US-based populations.

Item Type:	Article
Additional Information:	## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords:	KIM-1, nephrotoxicity, pediatric nephrology, proximal tubule
Depositing User:	Symplectic Admin
Date Deposited:	24 Mar 2017 14:30
Last Modified:	20 May 2024 12:22
DOI:	10.2217/bmm.14.36
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3006624