Evaluation of the ACR and SLICC classification criteria in juvenile-onset systemic lupus erythematosus: a longitudinal analysis


Lythgoe, H, Morgan, T, Heaf, E, Lloyd, O, Al-Abadi, E, Armon, K, Bailey, K, Davidson, J, Friswell, M, Gardner-Medwin, J et al (show 10 more authors) (2017) Evaluation of the ACR and SLICC classification criteria in juvenile-onset systemic lupus erythematosus: a longitudinal analysis. LUPUS, 26 (12). pp. 1285-1290.

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Abstract

Objectives The Systemic Lupus International Collaborating Clinics (SLICC) group proposed revised classification criteria for systemic lupus erythematosus (SLICC-2012 criteria). This study aimed to compare these criteria with the well-established American College of Rheumatology classification criteria (ACR-1997 criteria) in a national cohort of juvenile-onset systemic lupus erythematosus (JSLE) patients and evaluate how patients' classification criteria evolved over time. Methods Data from patients in the UK JSLE Cohort Study with a senior clinician diagnosis of probable evolving, or definite JSLE, were analyzed. Patients were assessed using both classification criteria within 1 year of diagnosis and at latest follow up (following a minimum 12-month follow-up period). Results A total of 226 patients were included. The SLICC-2012 was more sensitive than ACR-1997 at diagnosis (92.9% versus 84.1% p < 0.001) and after follow up (100% versus 92.0% p < 0.001). Most patients meeting the SLICC-2012 criteria and not the ACR-1997 met more than one additional criterion on the SLICC-2012. Conclusions The SLICC-2012 was better able to classify patients with JSLE than the ACR-1997 and did so at an earlier stage in their disease course. SLICC-2012 should be considered for classification of JSLE patients in observational studies and clinical trial eligibility.

Item Type: Article
Uncontrolled Keywords: Juvenile-onset systemic lupus erythematosus, ACR classification criteria, SLICC classification criteria
Depositing User: Symplectic Admin
Date Deposited: 07 Apr 2017 09:56
Last Modified: 19 Jan 2023 07:06
DOI: 10.1177/0961203317700484
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3006847
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